Anti-SHC1 Mouse Monoclonal Antibody [clone: 11F6]
ENZOADI905665100
- Antibody type:Primary
- Antigen name:SHC-transforming Protein 1
- Antigen symbol:SHC1
- Clonality:Monoclonal
- Clone:11F6
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- Isotype:IgG1
- Reactivity:Human,Mouse
- Western blot:Yes
- Seq:02
- Epitope:C-Terminal
- Form:Lyophilized
- Antigen synonyms:SHC|SH2 domain protein C1|FLJ26504|SHC1|p66SHC|Src homology 2 domain-containing-transforming protein C1|SHC-transforming protein 1|p52SHC|p66|SHCA
- Storage buffer:PBS containing 0,09% sodium azide, PEG, and sucrose.
- Storage temperature:–20 °C
- Shipping temperature:Shipped on blue ice
- Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of Shc.
- Purification:purified by thiophilic adsorption and size exclusion chromatography
- Pk:100 µG
The Src homology 2 domain containing (Shc) adaptor protein links growth factor, cytokine, and antigen receptor stimulation to the Ras signaling pathway, and plays a critical role in insulin signaling, tumorigenesis, and hematopoietic cell growth and differentiation. Structurally, Shc is composed of an N-terminal phosphotyrosine binding (PTB) domain, a medial CH1 domain, and a C-terminal SH2 domain. Upon binding to activate cell-surface receptors, Shc is phosphorylated at three tyrosine residues (Tyr239, Tyr240, Tyr317) triggering recognition of Shc by SH2-containing proteins such as Grb2.
Type: Primary
Antigen: SHC1
Clonality: Monoclonal
Clone: 11F6
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse