Anti-Insulin Receptor Mouse Monoclonal Antibody [clone: 10C3]
Catalog # ENZOADI905645100
Supplier: ENZO LIFE SCIENCES
Specifications
- Antibody type:Primary
- Antigen name:Insulin Receptor
- Antigen symbol:INSR
- Clonality:Monoclonal
- Clone:10C3
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- Isotype:IgG1
- Western blot:Yes
- Seq:02
- Form:Liquid
- Modification:phospho-Tyr1150, phospho-Tyr1151
- Storage buffer:PBS containing 50% glycerol, PEG, sucrose, and 0,09% sodium azide.
- Storage temperature:–20 °C
- Shipping temperature:Shipped on blue ice
- Immunogen:Synthetic peptide corresponding to a portion of human Insulin Receptor phosphorylated at Tyr1150/1151, conjugated to KLH.
- Purification:purified by thiophilic adsorption and size exclusion chromatography
- Pk:100 µG
Specifications
About this item
The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.
Type: Primary
Antigen: Insulin receptor
Clonality: Monoclonal
Clone: 10C3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human