Specifications
- Pk:100 µG
- Protein/peptide type:Recombinant
- Source:CHO cells
- Species:Mouse
- Tag sequence:Fc Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein synonyms:PD-1|Programmed Cell Death Protein 1
- Protein/peptide name:CD279
- Purity:>98% (SDS-PAGE)
- Sequence:26-169
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
Specifications
About this item
CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signallling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
Fusion-Tag: Fc Tag
This recombinant proteins is for research use only.