Specifications
- Pk:100 µG
- Protein/peptide type:Recombinant
- Source:CHO cells
- Species:Mouse
- Tag sequence:Fc Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein synonyms:B7-CD|Programmed Cell Death 1 Ligand 2|PDL2|PDCD1 Ligand 2
- Protein/peptide name:CD273
- Purity:>98% (SDS-PAGE)
- Sequence:20-219
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
Specifications
About this item
T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumour cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
- This recombinant proteins is for research use only.
Fusion-Tag: Fc Tag
This recombinant proteins is for research use only.