1924 Results for: "TMC HALLCREST"

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Wnt activator

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A major uterine luteolytic prostaglandin. Endogenous agonist of the prostanoid FP receptor (KD=1.0nM). Inhibits differentiation of 3T3-L1 preadipocytes.

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Inhibits the metalloprotease neprilysin (neutral endopeptidase 24.11) and neprilysin 2. Inhibits opioid-degrading enzymes, potentiating THC-induced antinociception. Potentiates the effects of natriuretic peptides. Blocks enzymatic degradation of luteinizing hormone releasing hormone (LHRH).

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Cell cycle inhibitor

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Nitric oxide donor

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Potent hepatotoxic and hepatocarcinogenic mycotoxin.

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Tyrosine kinase inhibitor. It has been shown to block TNFα induced cytotoxicity and to block glucocorticoid-induced COX-2 activity in human amnion cells (IC50=21μM). It is also reported to inhibit guanylyl cyclase.

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DPPIV/DPP4 inhibitor

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Putative endogenous member of a growing family of lipo-amino acids (N-acyl amino acids).

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Inhibitor of dopamine and norepinephrine transporters

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BIOARRAY™ 5-hmC Methylation Kit is used for the sequence specific detection of 5-hydroxymethylcytosine within DNA using a simple and efficient glucosylation reaction procedure.

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TrkA ligand

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Endogenous ceramide.

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L-Buthionine-sulfoximine (BSO) induces oxidative stress in cells by irreversibly inhibiting γ-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione.

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A potent inhibitor of the dual specificity phosphatase JSP-1 (IC50=18µM).

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Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg²⁺ ions and rapidly inactivated by N-acetylimidazole.

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Fluorogenic chromophore. Ex(max): 380nm, Em(max): 460nm. Reference compound.

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TdT inhibitor

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A selective estrogen receptor modulator (SERM). Displays anti-estrogen action along with anti-androgen action. In clinical use for prevention of postmenopausal osteoporosis. Reduces circulating levels of IL-6 and TNFα. Inhibits prostate carcinogenesis in transgenic rat model. May be useful for the prevention of hormone-related cancers.

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Potent and selective inhibitor of phospholipase D2 (PLD2) in cellular (PLD1 IC50 = 1900nM Calu-1 cells; PLD2 IC50 = 90nM HEK293-gfpPLD2 cells) and in vitro (hPLD1 IC50 = >20’000nM; hPLD2 IC50 = 500nM) assays.

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Ceramide-activated protein kinase activator.

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Na+ channel blocker

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PI3 kinase inhibitor

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Cell-permeable ceramide analog

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Na⁺/K⁺ ATPase inhibitor

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A novel inhibitor of glucosylceramide synthase as well as glucosidase I and II. Inhibits glucosylceramide synthase without ceramide accumulation and cell death. It is a potent inhibitor of human immunodeficiency virus (HIV) replication and syncytium formation in vitro. Restores chloride current in epithelial CF cells.

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Phospholipase substrate.

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Selective prostaglandin E₂ receptor (EP₁) antagonist. Useful at concentrations up to 10 µM, at which point it starts to block PGD₂ and TXA₂ receptors.

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Inosine-5'-monophosphate dehydrogenase inhibitor

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Antibiotic which suppresses nitric oxide (NO) toxicity in pancreatic islet cells. Inhibits protein synthesis by inhibition of elongation factor G at the level of the ribosome.