1924 Results for: "TMC HALLCREST"

Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].

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Ilimaquinone ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

ADP-ribosylation factor inhibitor

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L-744,832 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expression and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.

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Palmitoylethanolamide ≥98% (by TLC)

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Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.

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Calpeptin ≥98% (by TLC)

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Calpain and cathepsin inhibitor

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Virodhamine ≥98% (by TLC)

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Cannabinoid receptor ligand.

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Milrinone ≥97% (by TLC)

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PDE3 inhibitor

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Bisindolylmaleimide I ≥98% (by TLC)

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Potent and selective protein kinase C inhibitor which has been used effectively in platelets, Swiss 3T3 fibroblasts and macrophages. Inhibitory profile: PKC, IC50=0.02µM (inhibits α, ßI, ßII and γ subtypes with similar potency); PKA, IC50=2.0µM; phosphorylase kinase, IC50=0.7µM; insulin, EGF and PDGF receptor tyrosine kinases are not inhibited at concentrations up to 50µM.

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Wedelolactone ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

IKK inhibitor

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Monastrol ≥98% (by TLC)

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Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.

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Dorsomorphin ≥98% (by TLC)

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Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.

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4-Hydroxybenzylidenemalononitrile ≥98% (by TLC)

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The tyrphostins are well known tyrosine kinase inhibitors. However, tyrphostin 8 has been shown to inhibit calcineurin (IC50=21 µM) while displaying weak inhibition of EGFR tyrosine kinase (IC50=560 µM).

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Icilin ≥97% (by TLC)

Supplier: ENZO LIFE SCIENCES

TRPM8 activator.

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N-Arachidonoyldopamine ≥98% (by TLC)

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Activator of CB1 receptor and TRPV1

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2',5'-Dideoxyadenosine ≥98% (by TLC)

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Adenylate cyclase inhibitor

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DICA ≥98% (by TLC)

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Inhibitor of caspase-3 and caspase-7 binding to an allosteric site and not to the active site.

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FH535 ≥98% (by TLC)

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Inhibits the recruitment of the co-activators β-catenin and GRIP1

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Pravadoline ≥98% (by TLC)

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Cannabinoid receptor agonist.

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XAV939 ≥98% (by TLC)

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PARP5a inhibitor

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Kifunensine ≥98% (by TLC)

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Inhibits α-mannosidase. Inhibits asparagine-linked oligosaccharide processing. Immunomodulator.

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ITSA-1 ≥98% (by TLC)

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HDAC inhibitor

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Ac-IETD-AMC

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Caspase and granzyme substrate

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STAT3 Inhibitor V, Stattic ≥98% (by TLC)

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Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.