1924 Results for: "TMC HALLCREST"

Mixture of alamethicin homologs. Membrane permeabilizing antibiotic. Applications include increasing [32P] incorporation into phosphatidylinositol 4-phosphate and permeabilization of sarcoplasmic reticulum vesicles. Causes fusion of lipid vesicles.

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Wortmannin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

PI3 kinase inhibitor

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Ac-YVAD-AMC

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Caspase-1 inhibitor

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Lovastatin ≥98% (by TLC)

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HMG-CoA reductase inhibitor

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Dexamethasone ≥99% (by TLC)

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Glucocorticoid receptor ligand

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H-7 dihydrochloride ≥98% (by TLC)

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Inhibits PKA (Ki=3.0μM), PKG (Ki=5.8μM), MLCK (Ki=97μM) and PKC (Ki=6μM). Also inhibits myosin light chain kinase. Induces apoptotic DNA fragmentation and cell death. Inhibits telomerase activity in treated NPC-076 cells. Cell permeable.

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SB216763 ≥98% (by TLC)

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Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.

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Butyrolactone I ≥99% (by TLC)

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CDK inhibitor

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DMNQ ≥99% (by TLC)

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Inducer of intracellular ROS generation.

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α-Hydroxyalprazolam ≥98% (by TLC)

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Metabolite of alprazolam.

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Palmityltrifluoromethylketone ≥98% (by TLC)

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Inhibitor of both Ca2+-dependent cytosolic cPLA2 (IC50=45 µM) and Ca2+-independent phospholipases A2 iPLA2 (IC50=3.8 µM).

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Chaetocin ≥98% (by TLC)

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Methyltransferase inhibitor

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N-Arachidonylglycine ≥98% (by TLC)

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FAAH inhibitor

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Midostaurin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.