16886 Results for: "ENZO LIFE SCIENCES"

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beta-Amyloid dye

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Supersensitive spin label

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Cyclic hydroxylamine spin probe for in vivo, intraperitoneal and intravenous injections.

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Potent and selective inhibitor of microsomal and cytosolic epoxide hydrolase (IC50=68 nM). Inhibits epoxide hydrolysis of epoxyeicosatrienoic acids.

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Olomoucine is a purine derivative which acts as a potent and selective inhibitor of CDK1 (p34cdc2)/cyclin B and related kinases. It acts by competing for the ATP binding domain of the kinase. Of 35 protein kinases tested, olomoucine inhibited p33CDK2/cyclin A, p33CDK2/cyclin E, p34cdc2/cyclin B, p33CDK5/p35 and erk1 with IC50 of 7, 7, 7, 3 and 25µM respectively. The related kinases p34CDK4/cyclin D and p40CDK6/cyclin D3 were not inhibited or were less sensitive to olomoucine, IC50 > 1000 and 250µM respectively. PKC, PKA, PKG, CaM kinase II, MLC kinase, CK2, EGFR tyrosine kinase, p56lck, p56lyn, p60c-src, v-abl and insulin receptor tyrosine kinase are not inhibited or are weakly inhibited at 1mM. It delays mouse oocyte maturation and inhibits the growth of a variety of human cell lines including Rhabdomyosarcoma cell line Rh1, Rh18, Rh28 and Rh30; MCF-7, KB-3-1 and their adriamycin-resistant counterparts (IC50=18-86µM). It inhibits DNA synthesis in interleukin-2-stimulated T lymphocytes and triggers a G1 arrest similar to interleukin-2 deprivation. Can be used to synchronize cells in G1. Triggers apoptosis in target tumor cells in vitro and in vivo and in maturing cerebellar granule neurons. N9-Isopropyl-olomoucine and the negative control Iso-olomoucine are also available.

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HSP70 inhibitor

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Caspase substrate

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HDAC inhibitor

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Geranylgeranyl-donor.

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Prostanoid receptor ligand.

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TRAM-34 is a potent and selective inhibitor of the intermediate-conductance Ca2+-activated potassium channel (IKCa). It displays immunosuppressive activity and inhibits the proliferation of endometrial cancer cells.

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Muscarinic acetylcholine receptor antagonist.

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Spermine tetrahydrochloride

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Cyclic hydroxylamine spin probe for in vivo, intraperitoneal and intravenous injections.

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Cell permeable probe for the detection of intracellular oxidative stress.

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Topoisomerase I inhibitor

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Cell permeable inhibitor of the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α or okadaic acid through inhibition of IκBα degradation.

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TRP channel agonist.

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For the detection of apoptotic cells by flow cytometry.

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Positively charged rhodamine dyes (such as rhodamine esters and rosamines) are selectively localized in mitochondria, thus they are widely used for labeling mitochondria of live cells. Like JC-1,TMRE is widely used for measuring mitochondrial membrane potential, in addition to selectively staining mitochondria. Real-time imaging of mitochondrial membrane potential in individual cardiomyocytes within perfused rat hearts has been demonstrated with this dye, using 2-photon laser-scanning microscopy.

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Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

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Inhibitor of caspase-1 and -4

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Potent and selective serotonin uptake inhibitor

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Produced in E. coli.

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Recommended Applications: IF

Species reactivity: Human, Dog

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Apoptosis inducer.

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CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3  is also highly expressed in osteoclasts being important for bone resorption.

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Produced in E.coli.

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Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75NTR) (aa 1-250) is fused to the Fc portion of human IgG1.

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Anti-HSP90 Mouse Monoclonal Antibody [clone: 2D11B9]