58747 Results for: "Cayman Chemical"

Petunidin is an O-methylated anthocyanidin derived from delphinidin that imparts blue-red pigments to flowers, fruits, and red wine. Used to bind with and suppress the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis. Extracts from E. jambolana fruit, which is rich in anthocyanins including petunidin, have been used to suppress the proliferation of an HCT116 colon cancer cell line, as well as colon cancer stem cells.

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4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulphonic acid dipotassium salt ≥98%, crystalline solid fluorescent dye

Supplier: Cayman Chemical

bis-ANS is a high-affinity non-covalent extrinsic fluorescent dye used to analyze protein conformation. Its predominant interaction with proteins is through its hydrophobic phenyl and naphthyl rings.

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Purvalanol A ≥98%, crystalline solid

Supplier: Cayman Chemical

Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.

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Glycyrrhetic acid ≥98%

Supplier: Cayman Chemical

18β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC₅₀ = 35 μM). At 100 mg/kg/day, 18β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats. It inhibits mammalian DNA polymerases α, γ, κ and λ with IC₅₀ values of 16,1, 19,3, 15,8 and 13,7 μM, respectively. At 100-200 μM, 18β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.

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5-Aminosalicylic acid

Supplier: Cayman Chemical

5-Aminosalicylic acid

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Anti-sGC a1 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-sGC a1 Rabbit Polyclonal Antibody

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O-Acetylsalicylic acid

Supplier: Cayman Chemical

O-Acetylsalicylic acid

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5-Fluorouracil

Supplier: Cayman Chemical

5-Fluorouracil

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(6S)-Tetrahydrofolic acid ≥95%

Supplier: Cayman Chemical

(6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
(6S)-Tetrahydrofolic acid is 1,000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae.
(6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein.3

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5-Fluoro-2'-deoxyuridine (floxuridine)

Supplier: Cayman Chemical

5-Fluoro-2'-deoxyuridine (floxuridine)

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N-Octyl-β-D-glucopyranoside

Supplier: Cayman Chemical

N-Octyl-β-D-glucopyranoside

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Doxorubicin hydrochloride ≥98%

Supplier: Cayman Chemical

Doxorubicin is an anthracycline anti-tumour antibiotic which involves in inhibition of DNA topoisomerase II by inducing double-stranded DNA breaks. It is also involved in the inhibition of nucleic acid synthesis by intercalating within DNA. The accumulation of the p53 tumour suppressor protein leads to the apoptosis in cells.

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6-Cyano-7-nitroquinoxaline-2,3-dione ≥98%

Supplier: Cayman Chemical

CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively, versus IC50 = 25 μM for NMDA receptors).
This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors.

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Anti-JMJD2D Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-JMJD2D Rabbit Polyclonal Antibody

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Anti-PCSK9 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-PCSK9 Rabbit Polyclonal Antibody

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Anti-Nitrotyrosine Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-Nitrotyrosine Rabbit Polyclonal Antibody

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Pimaricin ≥95%, crystalline solid

Supplier: Cayman Chemical

Natamycin is a naturally-occurring macrolide polyene antifungal agent produced during fermentation by the bacterium S. natalensis, commonly found in soil. Used to treat fungal infections, including candida, aspergillus, cephalosporium, fusarium, and penicillium.