130016 Results for: "5-Chloromethyl-isoxazole-4-carboxylic+acid+ethyl+ester"

Supplier: NEW PIG

PIG absorbents in low cost, easy to close, hang and carry bag.

Supplier: Thermo Fisher Scientific

Simplify sample inventory. Thermo Scientific™ Linear barcoded tubes feature Thermo Scientific™ Nunc™ and Thermo Scientific™ Nalgene™ Cryotubes with directly printed barcodes that are more robust than labels. Choose from available noncustom options or call for customised options in a wide range of choices of code type, length and format.

Supplier: Bioss

Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

Supplier: Bioss

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Supplier: Pharmablock (USA)

4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZINE-5- 1 * 250 mg

Supplier: Abeba

The Food Trax line has been designed specifically for workplaces related to food processing and storage. The uppers are made of waterproof, low-porosity leather, which does not retain dirt and makes it easier to keep the shoes clean.

Supplier: Bioss

Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

Supplier: Bioss

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Supplier: Abcam

Sensitive, reproducible assay for initial screening of potential glutaminase inhibitors.

Supplier: ProSci Inc.

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. TRDMT1 is a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome.CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Supplier: THERMO SAVANT

Thermo Scientific™ Savant™ SpeedVac™ SPD1030 and SPD2030 vacuum concentrators are fully integrated systems that combine a concentrator, refrigerated cold trap, diaphragm pump and a vacuum gauge into a single, compact unit.

Supplier: AZELIS

IR3535® (Insect repellent 3535) 3-[N-n-butyl-N-acetyl] aminopropionsäure ethylester 1 * 1 L

Supplier: Hettich

The ROTOFIX 46 centrifuges are designed for use in research and industrial laboratories.

Supplier: witeg Labortechnik

Dispensers have a unique direct displacement piston system that is chemical-resistant and provides safe, smooth dispensing.

Supplier: MACHEREY-NAGEL

Photometric test kits for the determination of formaldehyde in water samples.

Supplier: ProSci Inc.

PPAPDC1A Antibody: Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide(NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. PPAPDC1A is preferentially expressed in endothelial cells. Studies of PPAPDC1A and PAP activity suggest that they may play a role in angiogenesis.

Supplier: LGC Standards PROMOCHEM

IBUPROFEN METHYLESTER 1 * 100 mg

Supplier: STEMCELL Technologies

10X Gentle collagenase/hyaluronidase in DMEM.

Supplier: ProSci Inc.

PPAPDC1B Antibody: Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide (NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. Knockdown experiments indicated that this protein is involved with multiple cell signaling pathways, including the JAK-Stat3, MAP kinase, and PKC pathways. PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22.

Supplier: witeg Labortechnik

Digital multi-position magnetic stirrer ideal for mixing and heating simultaneously. Ideal for heat sensitive procedures in microbiology, biochemistry or sample drying. Units feater a powder-coated steel body which is easy to clean. Each plate can accommodate a support rod.

Supplier: STEMCELL Technologies

For digestion of DNA.

Supplier: AZELIS

IR3535® (Insect repellent 3535) 3-[N-n-butyl-N-acetyl] aminopropionsäure ethylester 1 * 25 kg

Supplier: Pharmablock (USA)

[EN]TERT-BUTYL 3-AMINOPYRROLIDINE-1-CARB 1 * 10 g

Supplier: NEW PIG

PIG Blue is the most absorbent mat. Maximum absorbency soaks up more so you use less on big spills and high-volume leaks.

Supplier: Nitritex

These ambidextrous cleanroom gloves with beaded cuffs can be used in medical as well as in laboratory environments. Suitable for double-donning.

Supplier: Abcam

Simple, 1-step assay for screening potential α-amylase inhibitors.

Supplier: AZELIS

IR3535® (Insect repellent 3535) 3-[N-n-butyl-N-acetyl] aminopropionsäure ethylester 1 * 100 mL

Supplier: Pharmablock (USA)

[EN]TERT-BUTYL CIS-4-AMINO-3-FLUOROPIPER 1 * 5 g

Supplier: 3M

Thin and conformable, 3M™ polyester tape 8901 excels in high temperature masking operations such as powder coat painting. Coated with a silicone adhesive, this tape bonds to a variety of difficult surfaces. It is chemical-resistant and performs under a wide range of temperatures and environments.

Supplier: Nitritex

These ambidextrous nitrile gloves with beaded cuffs provide good resistance against a wide range of chemicals. They also provide superb tactility and comfort.