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Anti-PRKAA2 Rabbit Polyclonal Antibody
Anti-PRKAA2 Rabbit Polyclonal Antibody
Catalog # PRSI55-462
Supplier:  ProSci Inc.
New Product
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Anti-PRKAA2 Rabbit Polyclonal Antibody
Catalog # PRSI55-462
Supplier:  ProSci Inc.
New Product

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    5'-AMP-activated protein kinase catalytic subunit alpha-2
  • Antigen symbol:
    PRKAA2
  • Clonality:
    Polyclonal
  • Conjugation:
    Unconjugated
  • Flow cytometry:
    Yes
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • Reactivity:
    Human
  • Western blot:
    Yes
  • Epitope:
    Amino Acid Range = 145-173
  • Form:
    Liquid
  • Gene ID:
    P54646
  • Antigen synonyms:
    PRKAA2
  • Modification:
    None
  • Storage buffer:
    Supplied in PBS with 0,09% (W/V) sodium azide
  • Molecular weight:
    62 kDa
  • Storage temperature:
    Store at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Concentration:
    0,45 mg/ml
  • Shipping temperature:
    4 °C
  • Immunogen:
    This PRKAA2 (Thr172) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-173 amino acids from the Central region of human PRKAA2 (Thr172).
  • Purification:
    This antibody is purified through a protein A column, followed by peptide affinity purification.
  • Size:
    400 µl
  • Pk:
    400 µl

Specifications

About this item

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

For WB starting dilution is: 1:1000. For IHC-P starting dilution is: 1:10~50. For FACS starting dilution is: 1:10~50.

Type: Primary
Antigen: PRKAA2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: Rabbit Ig
Reactivity: Human