Cysteinyl Leukotriene Express is a competitive assay used for quantification of CysLT in urine, culture media, and other sample matrices.

• Detect all CysLTs (LTC₄, LTD₄, and LTE₄) in urine, tissue culture medium, and other sample matrices
• Assay 24 samples in triplicate or 36 samples in duplicate
• Measure CysLT levels down to 20 pg/ml
• Read: Colorimetric at 405 to 420 nm

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase (5-LO) pathway in leukocytes. LTC₄, LTD₄, and LTE₄ are collectively referred to as cysteinyl leukotrienes (CysLTs). LTC₄ and LTD₄ are potent mediators of asthma and hypersensitivity.

They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. The biological activity of LTE₄ is much lower in most systems studied, but its presence reflects the prior existence of LTC₄ and LTD₄.