Specifications
- Pk:10 µG
- Protein/peptide type:Recombinant
- Source:CHO cells
- Species:Human
- Environmentally Preferable:
- Tag sequence:DDDDK Tag
- Storage conditions:Stable for at least 6 months after receipt when stored at −20 °C.
- Biological activity:Induces B cell activation (as demonstrated by dose-dependent upregulation of CD86).
- Protein synonyms:ADIPOQ-CD40L|ACRP30headless:CD154|ACRP30headless:TNFSF5|ACRP30headless:CD40L
- Protein/peptide name:CD40L multimeric
- Purity:>95% (SDS-PAGE)
- Sequence:18-111
- Formulation:Lyophilized, Contains PBS.
Specifications
About this item
MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L™ has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
Fusion-Tag: DDDDK Tag
This recombinant proteins is for research use only.