Specifications
- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:Cells
- Species:Human
- Environmentally Preferable:
- Tag sequence:C-Fc tag
- Storage conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Protein synonyms:TNFRSF21|UNQ437/PRO868|DR6|CD358|Death Receptor 6|Tumor Necrosis Factor Receptor Superfamily Member 21
- Protein/peptide name:Death Receptor 6
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:61.7 kD
- Sequence:Gln42-Leu350
- Formulation:Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:Bioassay
Specifications
About this item
Tumour Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). DR6 is also expressed on the tumour cell lines and can be induced by TNF- alpha.
Fusion-Tag: C-Fc tag
This recombinant protein can be used for biological assays. For research use only.