Specifications
- Antibody type:Primary
- Antigen name:Cytochrome P450, Family 1, Subfamily B, Polypeptide 1
- Antigen symbol:CYP1B1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 488
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:1545
- Antigen synonyms:polypeptide 1 (glaucoma 3|cytochrome P450|microsomal monooxygenase|CYPIB1|primary infantile)|subfamily I (dioxin-inducible)|CP1B|cytochrome P450 1B1|xenobiotic monooxygenase|aryl hydrocarbon hydroxylase|P4501B1|flavoprotein-linked monooxygenase|GLC3A
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:450-485/543
- Purification:Purified by Protein A
- Pk:100 µl
Specifications
About this item
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: CYP1B1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype:
Reactivity: