The PATHO-GENE® HPV type 16/18 probe is a mixture of biotin-labeled HPV 16 and HPV 18-specific probes in buffered formamide and hybridisation enhancers.

The ENZO PATHO-GENE® HPV type 16/18 probe employs a mixture of the HPV 16 and HPV 18-specific probes that detect HPV types that have been associated with cervical intraepithelial neoplasia (CIN) and carcinoma in situ (CIS). The probe mixture is denatured and hybridised to the tissue section fixed and pretreated on the microscope slide. Specific hybridisation between the HPV DNA probe and DNA in the specimen is determined by the detection of biotin.