About this item
Reacts with a 70 kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.
Type: Primary
Antigen: ALPP
Clonality: Monoclonal
Clone: ALPP/870
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human
Specifications
- Catalog No:
- BNC400870-100
- BNC400870-500
- Antigen symbol:
- ALPP
- ALPP
- Antigen name:
- PLAP
- PLAP
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 640R
- CF® 640R
- Clone:
- Clone ALPP/870
- Clone ALPP/870
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 284255
- 284255
- Isotype:
- IgG2b kappa
- IgG2b kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Supplier: VWR Collection
Supplier: VWR Chemicals
Supplier: VWR Collection
Supplier: VWR Chemicals
Supplier: VWR Chemicals
Supplier: VWR Chemicals
Supplier: HEATHROW
Supplier: VWR Collection
Supplier: KIMBERLY CLARK
Supplier: VWR Collection
Supplier: VWR Collection