DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Type: Primary
Antigen: TOP1MT
Clonality: Monoclonal
Clone: TOP1MT/488
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
- Catalog No:
- BNC040488-500
- BNC040488-100
- Antigen symbol:
- TOP1MT
- TOP1MT
- Antigen name:
- Topoisomerase I MT
- Topoisomerase I MT
- Antigen synonyms:
- Type IB Topoisomerase|Topoisomerase I mitochondrial|TOP1MT|DNA topoisomerase I
- Type IB Topoisomerase|Topoisomerase I mitochondrial|TOP1MT|DNA topoisomerase I
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 405S
- CF® 405S
- Clone:
- Clone TOP1MT/488
- Clone TOP1MT/488
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 528574
- 528574
- Isotype:
- IgG2b kappa
- IgG2b kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
: VWR Collection
: KIMBERLY CLARK
: VWR Collection
: VWR Collection
: VWR Chemicals
: VWR Collection
: VWR Collection
: VWR Chemicals