Anti-CR1 Mouse Monoclonal Antibody (CF647) [clone: E11]

Recognizes a protein of 210-220 kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This MAb is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21 /CD35 /CD1a-. This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma.

Type: Primary
Antigen: CR1
Clonality: Monoclonal
Clone: E11
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Baboon, Cynomolgus monkey, Human, Rhesus monkey

Catalog No:
BNC470040-500
BNC470040-100

Antigen symbol:
CR1
CR1

Antigen name:
CD35 / CR1
CD35 / CR1

Antigen synonyms:
C3BR|Complement Component (3b/4b) receptor 1 including Knops blood group system|C3b/C4b receptor|KN|C3 binding protein|Knops blood group antigen|Complement receptor type 1|C4BR
C3BR|Complement Component (3b/4b) receptor 1 including Knops blood group system|C3b/C4b receptor|KN|C3 binding protein|Knops blood group antigen|Complement receptor type 1|C4BR