About this item
This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
Type: Primary
Antigen: BCL2
Clonality: Monoclonal
Clone: 8C8
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Monkey, Pig
Specifications
- Catalog No:
- BNCB0005-500
- BNCB0005-100
- Antigen symbol:
- BCL2
- BCL2
- Antigen name:
- bcl-2
- bcl-2
- Antigen synonyms:
- Apoptosis regulator Bcl-2|B-cell CLL/lymphoma-2
- Apoptosis regulator Bcl-2|B-cell CLL/lymphoma-2
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- Biotin
- Biotin
- Clone:
- Clone 8C8
- Clone 8C8
- Reactivity:
- Pig, Monkey, Human
- Pig, Monkey, Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 150749
- 150749
- Isotype:
- IgG1 kappa
- IgG1 kappa
- Western blot:
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- ImmunoPrecipitation:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Supplier: VWR Chemicals
Supplier: HEATHROW
Supplier: VWR Collection
Supplier: KIMBERLY CLARK
Supplier: VWR Collection
Supplier: VWR Chemicals
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Chemicals
Supplier: VWR Chemicals