Anti-CCL5/RANTES Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog # BOSSBS-1324R-A750

Supplier: Bioss

Catalog # BOSSBS-1324R-A750

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
CCL5/RANTES
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 750
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Pig,
Human,
Guinea pig,
Mouse
Epitope:
62-91/91
Form:
Liquid
Gene ID:
6352
Antigen synonyms:
RANTES|C-C motif chemokine 5|SCYA5|SIS-delta|Small-inducible cytokine A5|T cell-specific protein P228|Eosinophil chemotactic cytokine|eoCP|TCP228|D17S136E|CCL5|T-cell-specific protein RANTES|SISd
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
7.4/10 kDa
Storage temperature:
Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human CCL5
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Specifications

About this item

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:1679162, PubMed:13864, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilisation through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

Type: Primary
Antigen: CCL5/RANTES
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 62-91/91
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Pig, Guinea Pig