Collagen is one of the main structural components of the ECM in connective tissue and internal organs. It is mostly prevalent in skin, tendon, and bones. Type I Collagen is a heterodimer consisting of two α₁(I)-chains and one α₂(I)-chain, that spontaneously form a triple helix at neutral pH and 37 °C.

• Culture of cells with which hardly or don’t proliferate at all on glass or plastic surfaces
• Adherence of cells in culture media without serum or fibronectin
• Analysis of cell migration and morphology
• Change of cell appearance in 3D-collagen gels
• Maintenance of Cell differentiation status of higher cells
• Development of tissue like structures in-vitro and the application of them in wound healing processes

It is used in the production of gels, to embed cells. Type I Collagen-Gels are suitable for use as a substrate for adherent cells in a cell culture vessel or as a floating matrix in or on a cell culture medium.

Type 1 bovine calf collagen; 4 mg/ml in 0,1% acetic acid, act as a excellent substrate for the culture of epithelial cells and many other cell lines.