HiScreen Capto adhere ImpRes is a ready-to-use column pre-packed with BioProcess Capto adhere ImpRes strong anion exchange multimodal resin. The columns are an excellent choice for method optimization and parameter screening.

• High yields achieved through the high-resolution beads and selectivity of the ligand
• Efficient removal of aggregates, viruses, and main contaminants in MAb processes
• 10 cm bed height of HiScreen columns allows method optimization and parameter screening
• Reproducible results, scalable to BioProcess columns packed with the same chromatography media using the same linear fluid velocity

The multimodal functionality of Capto adhere ImpRes gives a different selectivity compared with traditional ion exchange columns and it binds proteins at high or low ionic strength.

Contaminants such as DNA, host cell proteins (HCP), leached protein A, aggregates, and viruses are efficiently removed, making Capto adhere ImpRes an excellent choice for purification of MAbs and other biomolecules with high aggregate content.

Capto adhere ImpRes is designed to allow effective, high-resolution polishing of MAb in the second or third step of a purification scheme downstream of the protein A capture step.