Anti-FANCD2 Mouse Monoclonal Antibody [clone: FI-17]
PIEAMA116570
- Antibody type:Primary
- Antigen name:Fanconi Anemia Complementation Group D2
- Antigen symbol:FANCD2
- Clonality:Monoclonal
- Clone:FI-17
- Conjugation:Unconjugated
- Host:Mouse
- ImmunoPrecipitation:Yes
- Reactivity:Human
- Western blot:Yes
- ChIP:Yes
- Format:ascites
- Form:Liquid
- Gene ID:2177
- Antigen synonyms:FANCONI PANCYTOPENIA TYPE 4|FAD|FA4|FANCD|FANCONI ANEMIA COMPLEMENTATION GROUP D|FACD|FAD2
- Storage buffer:ascites, 0.1% sodium azide
- Storage temperature:-20° C, Avoid Freeze/Thaw Cycles
- Shipping temperature:Ice
- Immunogen:FANCD2 fusion protein
- Size:100 µL
- Pk:100 µl
By Western blot, this antibody recognizes a band at ~155 and ~162 kDa (post-translationally modified form). Suggested positive control: Hela whole cell extract. Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein.
Type: Primary
Antigen: FANCD2
Clonality: Monoclonal
Clone: FI-17
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity: Human