Multimodal chromatography columns, HiTrap™ Capto Core 700

HiTrap™ Capto Core 700 is prepacked with Capto Core 700, a multimodal BioProcess medium for intermediate purification and polishing of viruses and other large biomolecules.

• High capacity and productivity in flowthrough mode
• Wide operational window of pH and conductivity
• Prepacked HiTrap™ columns for easy screening and convenient process development, as well as small scale purification

Capto Core 700 is a novel, layered bead chromatography resin consisting of a porous outer layer and ligand-activated core. The octylamine ligands found in the core of the beads are multimodal, being both hydrophobic and positively charged. These internalised ligands bind impurities strongly over a wide range of pH and salt concentration. The pores of the bead outer layer prevent large targets (Mr >700000) from binding to the ligands while smaller impurities can enter freely into the beads where they are captured.