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Anti-SIGLEC12 Rabbit Polyclonal Antibody

Anti-SIGLEC12 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. SIGLEC12, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.Western blots using four different antibodies against four unique regions of this protein target confirm the same apparent molecular weight in our tests.Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.

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VWR®, Kalibreringsvikter, klass E2

VWR®, Kalibreringsvikter, klass E2

Supplier: VWR Collection

Vikt i solitt, antimagnetiskt, polerat rostfritt stål.

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VWR®, Cleanroom Inner Wear

VWR®, Cleanroom Inner Wear

Supplier: VWR Collection

This disposable inner wear, made from non woven comfortable SMS, consists of a shirt and a pair of trousers. The set can be used as inner wear suits or work suits. Compatible for use in ISO Class 6 cleanroom environments.

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[EN]SERVICE WEIGHT SET 1 MG - 5 KG, OIML 1 * 1 SET

Supplier: Sartorius Balances

[EN]SERVICE WEIGHT SET 1 MG - 5 KG, OIML 1 * 1 SET

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[EN]COUNTERBALANCE AND WEIGHT SET 1.3C 1 * 1 Items

Supplier: Beckman Coulter

[EN]COUNTERBALANCE AND WEIGHT SET 1.3C 1 * 1 Items

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VWR® Cleanroom Garment Sets

VWR® Cleanroom Garment Sets

Supplier: VWR Collection

This single-use garment set includes overall, hood, boot covers and sleeve protectors, all made from breathable SMS fabric.

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[EN]CASE FOR WEIGHT SET EMPTY FOR 10KG K 1 * 1 Items

Supplier: Sartorius Balances

[EN]CASE FOR WEIGHT SET EMPTY FOR 10KG K 1 * 1 Items

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Vakuumpincett, aspirette®

Vakuumpincett, aspirette®

Supplier: HIRSCHMANN

Powered by rechargeable battery for picking up and placing flat objects up to a max. unit weight of 70 g.

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Accessories for QUANTOFIX®

Accessories for QUANTOFIX®

Supplier: MACHEREY-NAGEL

The accessories for the QUANTOFIX® product line help to improve the experience while using the test strips.

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Thermoreactors, CR series

Thermoreactors, CR series

Supplier: WTW

Thermoreactors for the determination of COD, total nitrogen or total phosphorus, ensure complete digestion of the sample and maintain the necessary high reaction temperature throughout the defined period. The most important temperatures and digestion times are stored in 8 fixed, easily selectable digestion programmes. CR 3200 and CR 4200 can be used with optional TFK CR external temperature probe, which can be used as a testing aid. It can be plugged into the interface in place of a cuvette, the set and actual temperatures can be output to either a printer or a PC, so function can not only be monitored, but also documented. Suitable for 16 mm cuvettes.

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VWR® pH 130, pH/mV Meter, Portable

VWR® pH 130, pH/mV Meter, Portable

Supplier: VWR Collection

These economical, robust, and waterproof pH meters are supplied in complete, ready to use kits that incorporate a robust carrying case, electrode and temperature sensor with different cable lengths and buffers.

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Genomic DNA isolation

Supplier: AGILENT

The RecoverEase DNA isolation kit recovers high-molecular-weight (100 to 500 kb) genomic DNA that is fully hydrated and ready for multiple applications the next day. DNA can be isolated from whole tissues such as liver, spleen, kidney, brain and testes without hazardous and tedious organic extractions or ethanol precipitations. The RecoverEase DNA isolation kit quickly isolates high-molecular-weight genomic DNA from a variety of tissues without organic solvent extractions or ethanol precipitation.

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NANOCONTROL® Standards for Photometric Test Kits

NANOCONTROL® Standards for Photometric Test Kits

Supplier: MACHEREY-NAGEL

This standard solution was specially developed for the control of MACHEREY-NAGEL test kits.

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Underwear set, 7416 UE

Underwear set, 7416 UE

Supplier: FRISTADS KANSAS

This set consists of a shirt with long sleeves and a pair of long johns. Both are made of 100% polyester.

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Isolator cleaning system, EasyClean® 360

Isolator cleaning system, EasyClean® 360

Supplier: BERKSHIRE

For efficient cleaning of compounding isolators, biological safety cabinets, laminar flow hoods and other mini environments is critical to the quality and purity of compounded products. The EasyClean® 360 System includes a light-weight, maneuverable cleaning tool along with easy-to-use laundered polyester knit covers. The padded knit cover and rounded edges of the mop head insure the tool does not scratch or damage surfaces.

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NANOCOLOR® Spectrophotometers

NANOCOLOR® Spectrophotometers

Supplier: MACHEREY-NAGEL

NANOCOLOR with high-class technology and reference detector technology (RDT) optics can work on smartphones or tablets and an icon-based menu.

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