"Stemcell Technologies"

Supplier: Stemcell Technologies

Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic growth factor that promotes proliferation, motility, survival, and differentiation. HGF binds and promotes the dimerization and activation of the receptor tyrosine kinase c-MET, and stimulates PI3K/AKT, FAK, JNK, and ERK1/2 signaling (Organ and Tsao). HGF stimulates migration of cells during embryogenesis, induces cell motility and scattering of epithelial cells, and regulates epithelial-mesenchymal transition. It is a chemoattractant for motor neurons, and regulates the development of sensory, sympathetic, parasympathetic, and cortical neurons as well as the proliferation of oligodendrocytes and glial development. Additionally, HGF is cytoprotective and regulates liver growth and regeneration (Nakamura et al.).

Supplier: Stemcell Technologies

Rat monoclonal antibody against human IL-4, PE-conjugated.

Supplier: Stemcell Technologies

Rat monoclonal IgG2b antibody against mouse CD45, PE-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD4, PerCP-Cy5.5-conjugated.

Supplier: Stemcell Technologies

Basic fibroblast growth factor (bFGF) is a prototypic member of the fibroblast growth factor family. Cytokines in the FGF family possess broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and are involved in a variety of biological processes including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). bFGF has the β-trefoil structure (Ponting and Russell), binds to the four FGF receptor (FGFR) family members, and activates JAK/STAT, PI3K, ERK1/2, and other receptor tyrosine kinase (RTK) signaling pathways. It supports the maintenance of undifferentiated human embryonic stem cells (Xu et al.; Kang et al.), stimulates human embryonic stem cells to form neural rosettes (Zhang et al.), and improves proliferation of human mesenchymal stem cells and enhances chondrogenic differentiation (Solchaga et al.).

Supplier: Stemcell Technologies

Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD4, Alexa Fluor® 488-conjugated.

Supplier: Stemcell Technologies

(C3H × BALB/c) F1 hybrid monoclonal IgG2a antibody against mouse NK1.1 (CD161).

Supplier: Stemcell Technologies

For probe-based assays and arrays.

Supplier: Stemcell Technologies

ALDH enzyme inhibitor used as a control in the ALDEFLUOR™ assay system.

Supplier: Stemcell Technologies

Medium and Transwell® inserts for human airway epithelial cells cultured at the air-liquid interface.

Supplier: Stemcell Technologies

Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF/platelet-derived growth factor (PDGF) family of proteins. VEGF-C is a potent angiogenic factor and promotes lymphangiogenesis, endothelial cell growth and survival, and can affect blood vessel permeability. VEGF-C is expressed in a range of tissues, but is not expressed in peripheral blood lymphocytes. VEGF-C forms a non-covalent, cell surface-associated, disulfide-linked homodimer that can bind and activate VEGF receptors 2 (VEGFR-2 [Flk1]) and 3 (VEGFR-3 [Flt4]). Interaction with VEGFR-2 results in physiological and intratumoral neoangiogenesis and vessel sprouting (Cao et al.; Tammela et al.), whereas interaction with VEGFR-3 is critical for lymphangiogenesis (Karkkainen et al.; Laakkonen et al.; Mäkinen et al.). Overexpression of VEGF-C in tumor cells has been shown to result in enhanced lymph flow and increased metastasis to regional lymph nodes (Hoshida et al.; Mandriota et al.; Padera et al.; Skobe et al.).

Supplier: Stemcell Technologies

Serum-free methylcellulose-based medium with recombinant cytokines for human cells.

Supplier: Stemcell Technologies

Stimulating T cells with SARS-CoV-2 (Spike Protein) Omicron XBB.1.5.X Mutation peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This pool is provided as two lyophilised mixtures (subpools) from the spike glycoprotein of SARS-CoV-2 Omicron XBB.1.5.X subvariant. The subpools contain 158 and 157 peptides, respectively, for a total of 315 peptides, and consist of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 1269 on the spike protein. Through interactions with the angiotensin-converting enzyme 2 (ACE2) receptor, the spike protein enables the virus to attach to the cell membrane, and plays a critical role in viral entry (Hoffmann et al.; Walls et al.). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

Supplier: Stemcell Technologies

Immunodensity isolation of untouched myeloid cells for lineage-specific chimerism analysis.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD16, unconjugated.

Supplier: Stemcell Technologies

B cell activating factor (BAFF) is part of the tumor necrosis factor (TNF) superfamily and is expressed by monocytes, macrophages, dendritic cells, and neutrophils (Mackay and amp; Browning; Scapini et al.). It binds to 3 receptors: BAFF-R, TACI, and BCMA, all of which are expressed by B cells at various times in their development (Liu and amp; Davidson). BAFF-R signaling activates the NF-kB signaling pathway, and promotes B cell survival, Ig class switching, and antigen presentation (Bossen and amp; Schneider; Liu and amp; Davidson; Naradikian et al.). BAFF also has functions in other cell types: it promotes monocyte survival and activation, proinflammatory cytokine secretion, and differentiation into macrophages (Chang et al.), and co-stimulates anti-CD3-mediated activation of human T cells (Huard et al.; Mackay and amp; Leung).