"Stemcell Technologies"

Supplier: Stemcell Technologies

Defined, animal component-free medium for differentiation of human ES and iPS cells to multiple lineages.

Supplier: Stemcell Technologies

Immunodensity isolation of untouched B cells.

Supplier: Stemcell Technologies

Complete kit including collagen, media, staining kit and chamber slides for human CFU-Mk assays.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee CD45, APC-conjugated.

Supplier: Stemcell Technologies

Basal medium for expansion of human neural stem and progenitor cells.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee, gibbon TRA-2-49 (tissue non-specific alkaline phosphatase), unconjugated.

Supplier: Stemcell Technologies

McCoy's 5A medium.

Supplier: Stemcell Technologies

For detection and measurement of human immunoglobulin M.

Supplier: Stemcell Technologies

Vascular endothelial growth factor D (VEGF-D) is a member of the VEGF/platelet-derived growth factor (PDGF) family of proteins. VEGF-D is a potent angiogenic factor and promotes lymphangiogenesis, endothelial cell growth and survival, and can affect blood vessel permeability. VEGF-D is expressed in the lung, heart, small intestine, fetal lung, and at lower levels in the pancreas, colon, and skeletal muscle (Otrock et al.; Roy et al.; Stacker et al.; Yamada et al.). VEGF-D is a ligand for VEGF receptors 2 (Flk1) and 3 (Flt4) (Baldwin et al.). VEFGR-3 is highly expressed in lymphatic endothelial cells and is essential for their growth and differentiation (Otrock et al.; Roy et al.). Binding of VEGF-D to neuropilins contributes to VEGFR-3 signaling during lymphangiogenesis, whereas binding to integrin α9β1 promotes endothelial cell adhesion and migration (Roy et al.; Otrock et al.). During embryogenesis, VEGF-D also plays a role in the formation of the venous and lymphatic systems.

Supplier: Stemcell Technologies

Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf andamp; Nicola). G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit et al.), the activation of metalloproteases that cleave VCAM-1 (Levesque et al.), and the release of norepinephrine from the sympathetic nervous system (Katayama et al.), leading to the release or mobilisation of hematopoietic stem cells from the bone marrow into the periphery. The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2b antibody against human CD235ab (glycophorin A/B), FITC-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG2a antibody against human CD51 (integrin αV), biotin-conjugated.

Supplier: Stemcell Technologies

Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi and Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto and Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi and Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick et al.). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto and Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata et al.). This product is animal component-free.

Supplier: Stemcell Technologies

Rat monoclonal IgG2a antibody against human, mouse, cat CD45R (B220), APC-conjugated.

Supplier: Stemcell Technologies

Goat polyclonal antibody against mouse IgG (H+L).

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human MUC1 (CD227), unconjugated.