5269 Results for: "ENZO LIFE SCIENCES"
Anti-HSPA8 Rabbit Polyclonal Antibody
Supplier: ENZO LIFE SCIENCES
The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1's role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate binding domain of Hsd70 cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.
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Anti-MD-2 Rabbit Polyclonal Antibody
Supplier: ENZO LIFE SCIENCES
MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs recognize different pathogen-associated molecular patterns, thereby linking the innate and adaptive immune responses.
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Anti-HDJ1 Rabbit Polyclonal Antibody
Supplier: ENZO LIFE SCIENCES
Hsp40/Hdj1 is a cytosolic co-chaperone belonging to the class DnaJ, named after its homolog in E. coli. Hsp40 functions in protein folding by binding nascent peptides and unfolded substrates and facilitating substrate interaction with Hsp70. Binding of Hsp40 to Hsp70 increases Hsp70 ATP hydrolysis and substrate binding, which is reversed by the action of nucleotide exchange factors (GrpE in E. coli). Repeated cycles of Hsp40/Hsp70 peptide binding and ATP hydrolysis prevent premature folding and aggregation, promoting protein maturation throughout the cell.
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Why Choose Corning Fetal Bovine Serum?
Our vertically integrated FBS serum supply chain, from collection to scientist, allows us to provide a consistent supply of FBS.
Anti-CPN10 Rabbit Polyclonal Antibody
Supplier: ENZO LIFE SCIENCES
Chaperonin 10 (Cpn10 or Hsp10), is the ~10 kDa mammalian equivalent to GroES of E. coli. Chaperonins play fundamental roles in the folding, assembly, and translocation of other proteins.
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AC-55469 ≥98%
Supplier: ENZO LIFE SCIENCES
AC-55649 is potent and subtype selective agonist at RARβ2 ( EC50=6.9 µM). It inhibits proliferation of MCF-7 cells and induces differentiation in a neuronal cell line.
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TCPOBOP ≥98%
Supplier: ENZO LIFE SCIENCES
Constitutive androstane receptor (CAR) activator.
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Raloxifene hydrochloride ≥98%
Supplier: ENZO LIFE SCIENCES
A selective estrogen receptor modulator (SERM). Displays anti-estrogen action along with anti-androgen action. In clinical use for prevention of postmenopausal osteoporosis. Reduces circulating levels of IL-6 and TNFα. Inhibits prostate carcinogenesis in transgenic rat model. May be useful for the prevention of hormone-related cancers.
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SBHA ≥95%
Supplier: ENZO LIFE SCIENCES
Induces cellular differentiation. Inhibits histone deacetylation.
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Ellipticine ≥98%
Supplier: ENZO LIFE SCIENCES
A DNA-intercalating antitumor agent. Inhibits DNA topoisomerase II. Inhibits the phosphorylation of p53 in Lewis lung carcinoma cells and induces apoptosis. Inhibits cytochrome P-450-1A1.
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L-Buthionine sulphoximine ≥97%
Supplier: ENZO LIFE SCIENCES
L-Buthionine-sulfoximine (BSO) induces oxidative stress in cells by irreversibly inhibiting γ-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione.
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N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride hydrate (HBED) ≥95%
Supplier: ENZO LIFE SCIENCES
Potent iron chelator
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Bordetella pertussis toxin
Supplier: ENZO LIFE SCIENCES
Bordetella pertussis toxin (Islet-activating protein, PTX) from Bordetella pertussis, strain NCTC 10739. is a high purity toxin applicable to ELISA, antibody capture, cytotoxicity studies, LINE assay.
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Resveratrol ≥98%
Supplier: ENZO LIFE SCIENCES
Antioxidant. SIRT1 activator.
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Anti-FN1 Mouse Monoclonal Antibody
Supplier: ENZO LIFE SCIENCES
Fibronectins are high molecular weight, disulphide-linked, dimeric cell adhesion glycoproteins found in basement membranes and in the interstitial connective tissue matrix. A single fibronectin gene is subject to alternative splicing in a cell-type-, development- and age-regulated manner which gives rise to multiple molecular forms. In addition to their prominent role in adhesion, fibronectins have been reported to mediate various aspects of cellular interaction, including migration during development and wound-healing, haemostasis, and the regulation of cell growth and differentiation. Cellular fibronectins (cFn) are found in low amounts in normal human plasma and tissues, but they are abundant in the plasma of carcinoma patients and in the stroma of various carcinomas. In contrast, a soluble form of fibronectin produced by hepatocytes is readily detectable in plasma and becomes deposited in pericellular matrices and within tissues. This form of fibronectin, referred to as ‘plasma fibronectin’ (pFn), differs from cFn by the absence of an amino acid sequence, known as extra domain A1.
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Cholera Toxin (Vibrio cholerae) G Protein Activator
Supplier: ENZO LIFE SCIENCES
G protein activator.
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Clostridium difficile toxin B
Supplier: ENZO LIFE SCIENCES
Clostridium difficile toxin B from Clostridium difficile, strain VPI10463 is a high purity toxin applicable to ELISA, antibody capture, cytotoxicity studies and LINE assay.
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Mca-Pro-Leu-Ala-Nva-Dap(Dnp)-Ala-Arg-NH2
Supplier: ENZO LIFE SCIENCES
MMP-2 substrate
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AH-6809 ≥98%
Supplier: ENZO LIFE SCIENCES
Selective prostaglandin E₂ receptor (EP₁) antagonist. Useful at concentrations up to 10 µM, at which point it starts to block PGD₂ and TXA₂ receptors.
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Synthetic melittin
Supplier: ENZO LIFE SCIENCES
PLA2 stimulatory bee venom peptide. Sequence is similar to Phospholipase A2 Activating Peptide (Prod. No. ALX-165-007). Activates PLA2 (5-fold at 10 µg/ml) in BC3H1 cells. For additional technical information see melittin (natural) (Prod. No. ALX-162-006).
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Human MMP8 proenzyme (from neutrophils)
Supplier: ENZO LIFE SCIENCES
MMP-8 is a glycoprotein containing complex N-linked oligosaccharides.
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Human recombinant Leptin (from E. coli)
Supplier: ENZO LIFE SCIENCES
Produced in E. coli. Homologous to human serum leptin.
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Anti-Peptide Tyrosine Tyrosine Mouse Monoclonal Antibody
Supplier: ENZO LIFE SCIENCES
Peptide tyrosine-tyrosine (PYY) amide is a 36 amino-acid. PYY is a member of the pancreatic polypeptide (PP) family of peptides (neuropeptide Y (NPY), PYY and PP). While NPY is localized in neurons (both in the central and peripheral nervous system) and PP in the pancreatic islets, PYY is found in both neurons and the gut. PYY is released in response to food intake from the same endocrine cells (L cells) in the intestinal mucosa as the glucagon-like peptides, and inhibits gall bladder secretion, gut motility and pancreatic secretion. These effects are similar to those of PP and overlap with the gut inhibitory activity of GLP-1.