Specifications
- Antikroppstyp:Primär
- Antikroppsnamn:CD44 molecule (Indian blood group)
- Antigensymbol:CD44
- Klonalitet:Monoclonal
- Klon:IM7
- Konjugation:PerCP (Peridinin-Chlorophyll Protein Complex)/Cy5.5®
- Flödescytometri:Yes
- Värd:Rat
- Isotyp:IgG2b kappa
- Korsad adsorption:No
- Form:liquid
- Gen-ID:P16070; P15379
- Antigen synonymer:CD44
- Storage buffer:Phosphate-buffered aqueous solution, ≤0,09% Sodium azide, may contain carrier protein/stabiliser, ph 7,2.
- Förvaringstemperatur:The product should be stored undiluted at 4 °C and should be protected from prolonged exposure to light. Do not freeze.
- Shipping temperature:4 °C
- Rening:The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
- Förp.:0,025 mg
Specifications
About this item
The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.
Type: Primary
Antigen: CD44
Clonality: Monoclonal
Clone: IM7
Conjugation: PerCP (Peridinin-Chlorophyll Protein Complex)/Cy5.5®
Epitope:
Host: Rat
Isotype: IgG2b kappa
Reactivity: Human;Mouse