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Anti-MYLIP Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Anti-MYLIP Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-9674R-A750
Supplier:  Bioss
Anti-MYLIP Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-9674R-A750
Supplier:  Bioss

Specifications

  • Antikroppstyp:
    Primär
  • Antikroppsnamn:
    MYLIP
  • Klonalitet:
    Polyclonal
  • Konjugation:
    Alexa Fluor® 750
  • Värd:
    Rabbit
  • ImmunKemi:
    Yes
  • ImmunoFluorescens:
    Yes
  • Isotyp:
    IgG
  • Reaktivitet:
    Human,
    Rat,
    Mouse
  • Western blot:
    Yes
  • Epitop:
    51-150/445
  • Form:
    Liquid
  • Gen-ID:
    29116
  • Antigen synonymer:
    BM-023|BZF1|MIR|Inducible degrader of the LDL-receptor|MYLIP|E3 ubiquitin-protein ligase MYLIP|Myosin regulatory light chain interacting protein|PP5242|IDOL
  • Modifiering:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Molekylvikt:
    50 kDa
  • Förvaringstemperatur:
    Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Koncentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human MYLIP
  • Rening:
    Purified by Protein A
  • Förpackningstyp:
    Vial
  • Förp.:
    100 µl

Specifications

About this item

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilisation of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Type: Primary
Antigen: MYLIP
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 51-150/445
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat