Specifications
- Antikroppstyp:Primär
- Antikroppsnamn:Microphthalmia-Associated Transcription Factor
- Antigensymbol:MITF
- Klonalitet:Polyclonal
- Konjugation:FITC (Fluorescein Isothiocyanate)
- Värd:Rabbit
- ImmunKemi:Yes
- Isotyp:IgG
- Reaktivitet:Human,Rat,Mouse
- Korsad adsorption:No
- Form:liquid
- Gen-ID:4286
- Antigen synonymer:bHLHe32|BHLHE32|MITF|Class E basic helix-loop-helix protein 32|Microphthalmia-associated transcription factor
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Förvaringstemperatur:Store at 4°C for 12 months
- Koncentration:1 μg/μl
- Shipping temperature:4°C
- Rening:Purified by Protein A
- Förp.:100 µl
Specifications
About this item
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: MITF
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat