Specifications
- Antikroppstyp:Primär
- Antikroppsnamn:Solute Carrier Family 5 Member A3
- Antigensymbol:SLC5A3
- Klonalitet:Polyclonal
- Konjugation:Cy7®
- Flödescytometri:Yes
- Värd:Rabbit
- ImmunKemi:Yes
- Isotyp:IgG
- Reaktivitet:Human,Rat,Mouse
- Korsad adsorption:No
- Form:liquid
- Antigen synonymer:Na+/myo-inositol cotransporter|SC5A3_HUMAN|SLC5A3|Na+/myo inositol cotransporter|SMIT2|solute carrier family 5 inositol transporters|member 3|Sodium/myo inositol cotransporter|SMIT|Solute carrier family 5 member 3.|sodium/myo inositol cotransporter 1|Sodium/myo-inositol cotransporter
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Förvaringstemperatur:Store at 4°C for 12 months
- Koncentration:1 μg/μl
- Shipping temperature:4°C
- Rening:Purified by Protein A
- Förp.:100 µl
Specifications
About this item
Myo-inositol is involved in many important aspects of cellular regulation including membrane structure, signal transduction and osmoregulation. It is taken up into cells by the sodium/myo-inositol cotransporter (SMIT). SMIT activity maintains intracellular concentrations of myo-inositol; it is upregulated in response to hypertonic stress. The human SMIT protein is encoded by the SLC5A3 gene, which maps to chromosome 21q22.12. It is expressed in many human tissues, such as brain, kidney and placenta. Specifically, SMIT is abundantly expressed throughout the whole brain and spinal cord in fetal rat, but is downregulated in adult rat brain with the exception of the choroid plexus, where SMIT expression remains high. In kidney, SMIT localizes to the baso-lateral membranes of the thick ascending limb of Henle (TAL) and the inner medullary collecting duct (IMCD). Impaired SMIT activity is implicated in the pathogenesis of diabetes and Down syndrome.
Recommended Dilutions: Flow Cytometry: 1:20-100; IF(IHC-P): 1:50-200
Type: Primary
Antigen: SLC5A3
Clonality: Polyclonal
Clone:
Conjugation: Cy7®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat