Solid supported liquid/liquid extraction (SLE) is a fast effective sample preparation technique that provides considerable benefits over liquid/liquid extraction (LLE) protocols for removal of phospholipids from biological samples.

• Greater reproducibility and recoveries compared to LLE techniques
• Prevents emulsification often associated with LLE as the sample and water immiscible solvents are not in direct contact
• Reduced solvent requirements compared to LLE
• Can be completely automated unlike LLE
• Improved cleanliness of sample extract compared to protein precipitation techniques
• Improved sensitivity compared to protein precipitation techniques