Antibiotics & Antimycotics

Antibiotics and Antimycotics are a type of antimicrobial drug used in the treatment and prevention of bacterial infections. They may either kill or inhibit the growth of microorganisms.

In science, antibiotics and antimycotics are mostly used in cell culture. They are used to select for a specific type of cells, either when cultivating mammal cells to exclude bacteria or when selecting for genetically modified cells which carry a resistance gene.

PanReac AppliChem antibiotics and antimycotics can be used for small assays and larger scale applications. Here, you can find a selection of the most commonly used products from this range.

Ensure reproducibility for your cell culture or microbiology experiments with PanReac AppliChem antibiotics and antimycotics.

List of selected antibiotics:

Product No.	Description	Target organism	Mode of action	Recommended working concentration	Stock solution
A1907	Amphotericin B	fungi, yeast	binds to sterols with planar structure and impairs with membrane permeability	0.25 µg/ml >3 µg/ml fungicidal	30-40 mg/ml in DMSO
A3784	Blasticidin S hydrochloride	Prokaryotes, Eukaryotes	inhibits protein biosynthesis by preventing the formation of the peptide bond	3-100 µg/ml	50 mg/ml in H₂O or buffer store at +4°C - -20°C
A1491	Carbenicillin disodium salt	gram negative germs, enterococci	inhibits cell wall synthesis (transpeptidase) in growing bacteria	20-60 µg/ml	50 mg/ml in H₂O/MeOH 1:1 store at -20°C
A0879	Cycloheximide (Actidion)	fungi, eukaryotes	binds to 80 S ribosome in eukaryotic cells; inhibits formation of peptide bond	10 µg/ml	10 mg/ml
A1492	Gentamycin sulfate	gram positive/ negative germs	inhibits protein synthesis by binding to the L6 protein of the 50 S ribosomal subunit	15-50 µg/ml	10-20 mg/ml in water, formamide
A2175	Hygromycin B - Solution			10-400 µg/ml	ca. 41 mg/ml in H₂O; store at -20°C
A1493 & A4789	Kanamycin sulfate & Kanamycin Sulfate (Ph. Eur., BP) pure, pharma rade	gram positive/ negative cocci & bacteria	inhibits protein synthesis (translocation)	10-100 µg/ml	10 mg/ml in H₂O store at -20°C
A0890	Polymyxin B sulfate	gram negative bacteria - non- proliferating germs too	interaction with phospholipid components of the bact. cell membrane; changes permeability of the membrane and causes efflux of essential plasma compounds	50 µg/ml	25 mg/ml H₂O, MeOH
A1839	Vancomycin hydrochloride	bacteriostatic and bacterizide against gram positive cocci and bacteria	amphoteric glyopeptide antibiotic; binds to bacterial cell wall precursors (peptidoglycans)	1-25 µg/ml	soluble in water ›100 mg/ml

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