238886 Results for: "single-use assemblies"

Supplier: OMEGA BIO-TEK

Pre-scripted solution for the purification of cfDNA from up to 4 ml plasma samples.

Supplier: STEMCELL Technologies

Stromal cell-derived factor 1 alpha (SDF-1α) is a member of the CXC group of chemokines that binds to the G-protein coupled receptor, CXCR4, to regulate migration, proliferation, differentiation, and survival of many cell types including hematopoietic stem cells, B cells, and T cells. It is produced by bone marrow stromal cells, osteoblasts, endothelial cells, and neuronal cells. SDF-1α was first identified as the pre-B-cell growth-stimulating factor (PBSF) in the mouse bone marrow-derived stromal cell line, PA6, in the growth of B cell precursors (Hayashi et al.). SDF-1α primarily regulates cell motility during development and adulthood, including the homing of hematopoietic stem cells and neutrophils to fetal bone marrow during ontogeny (Ara et al. 2003a) and the recruitment of endothelial progenitor cells from bone marrow during angiogenesis in adulthood (Zheng et al.). In addition to its role in hematopoiesis, the SDF-1α/CXCR4 signaling pathway is also essential for the homing of primordial germ cells to gonads (Ara et al. 2003b), the migration of granule cells in the cerebellum during neurogenesis (Zou et al.), and the migration of breast cancer cells to sites of metastasis (Muller et al.).

Supplier: STEMCELL Technologies

Macrophage colony-stimulating factor (M-CSF) is a homodimeric glycoprotein growth factor that regulates proliferation and differentiation of myeloid hematopoietic progenitor cells to mononuclear phagocytic cell lineages, including monocytes, macrophages, and osteoclasts. M-CSF is a crucial factor for the development of tissue-resident macrophages in most tissues (Ginhoux and Jung). It is required for the maturation and activation of monocytes and macrophages, and regulates inflammatory responses in conjunction with other stimuli such as IFN-γ, LPS, and IL-4 (Murray et al.). M-CSF is also required for bone resorption by osteoclasts, and is involved in the development and regulation of the placenta, mammary gland, and brain. M-CSF is produced by monocytes, fibroblasts, osteoclasts, stromal cells, endothelial cells, and tumor cells (Chockalingam and Ghosh). M-CSF exerts its biological effects by signaling through a receptor tyrosine kinase (CSF-1R or M-CSF-R) encoded by the c-fms proto-oncogene (Hamilton). CSF-1R shares similar structural features with other growth factor receptors, including the stem cell factor (SCF) receptor, platelet-derived growth factor receptor (PDGF-R), and Flt3/Flk-2 receptor tyrosine kinase. Stimulation of the CSF-1R upon binding to M-CSF activates MAPK, PI3K, and PLCγ signaling pathways (Chockalingam and Ghosh). Human and mouse M-CSF sequences are highly conserved both at nucleotide and amino acid levels (80% homology; DeLamarter et al.).

Supplier: STEMCELL Technologies

Interleukin 17A (IL-17A) is the founding member of the family of cytokines that includes Interleukin 17B through Interleukin 17F. It is a potent proinflammatory cytokine that plays a key role in defense against pathogens. IL-17A and IL-17F signal as homodimers or heterodimers through the same receptor, and activate NF-kB, MAPK, and C/EBP pathways (Gaffen). IL-17A receptor is expressed on a variety of cell types, including hematopoietic cell compartments. IL-17A is produced by T helper 17 cells, CD8+ T cells, γδ T cells, natural killer T cells, B cells, neutrophils, innate lymphoid cells and mesenchymal stromal cells (MSCs; Zenobia and amp; Hajishengallis; Mojsilovic et al.). IL-17A receptor is expressed at particularly high levels on stromal cells, including MSCs. IL-17A increases the frequency and the average size of colony-forming units-fibroblast derived from bone marrow, as well as the proliferation of bone marrow-derived MSCs. IL-17A suppresses osteogenic differentiation and bone formation of bone marrow-derived MSCs. The action of IL-17A on hematopoiesis is deeply reliant on the microenvironment and the induction of other regulators. In healthy mouse bone marrow, IL-17A stimulates myeloid and early stage erythroid progenitor cells but inhibits late stage erythroid progenitor cells (Mojsilovic et al.).

Supplier: STEMCELL Technologies

R-Spondin-1 (RSPO1) is the prototype member of the R-Spondin (RSPO) protein subfamily of a superfamily of thrombospondin type 1 repeat (TSR-1)-containing proteins (Chen et al.; Kamata et al.; Kazanskaya et al.; Kim et al.). Although unable to initialize signaling, RSPO family members are potent enhancers of WNT signaling (Cruciat and Niehrs; de Lau et al.; Kamata et al.; Kazanskaya et al.). They are characterized by a TSR-1 domain, a carboxy-terminal region with positively charged amino acids, and two N-terminal furin-like cysteine-rich repeats (Glinka et al.; Kazanskaya et al.). R­-Spondin-1 activates β­-catenin signaling via the WNT signaling cascade and by indirectly increasing low-density lipoprotein receptor-related protein 6 (LRP6) on the cell surface. It does this by binding leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), and competing with WNT antagonist DKK­1 for binding to the WNT co­receptors, Kremen and LRP­6, which reduces DKK­1-­mediated internalization of LRP6 (Binnerts et al.). RSPO1 is involved in a wide range of pleiotropic roles during embryogenesis, it is required for the specification of hematopoietic stem cells, and it has been shown to be important in the growth, survival, and migration of ovarian cancer cells (Cruciat and Niehrs; de Lau et al.; Genthe and Clements; Liu et al.).

Supplier: Greiner Bio-One

Manufactured from high quality polypropylene, Cryo.s freezing tubes are suitable for storage of cell cultures, tissue samples, microbiological samples, material of human or animal origin such as blood, serum, and sperm, as well as antibodies, RNA, DNA, and protein samples.

Supplier: Portwest

These traffic jacket combining a 300D outer shell for complete waterproof protection and detachable polar fleece for optimum warmth.

Supplier: Thermo Fisher Scientific

PS, non sterile, without lid. Available with a choice of surface chemistries: Amino surface for rapid coupling of peptides and proteins, streptavidin surface for rapid coupling of biotinylated biomolecules such as peptides, antibodies, oligonucleotides or haptens. Also available clear, for colorimetric assays and sample storage, white, for luminescence and fluorescence assays, or black, for fluorescence assays.

Supplier: Ansell

This technically advanced glove is made of polychloroprene. While it provides the comfort and flexibility of natural rubber gloves, its neoprene composition offers better chemical resistance for optimal product and worker protection.

Supplier: Ansell

Chemical-resistant gloves with a unique multi-layer design, for broader protection from acids and hydrocarbons.

Supplier: TESTO

These digital thermometers provide a probe socket for highly accurate PT100 probes and two sockets for fast action thermocouple probes. Readings from up to three additional temperature probes can be displayed. The data is recorded in the instrument and can be analysed through graphics and tables.

Supplier: Brady

The BradyPrinter i7100 industrial thermal transfer benchtop printer is ideal for customers requiring reliable high volume printing on lots of different materials within the Aerospace, Defence and Mass Transit, Electronics, Automotive, Logistics, Electrical, Voice-Datacom and LAB markets. It guarantees accurate printing on sleeves, tags, labels, tapes, cable markers and much more.

Supplier: DuPont

These garments are made from a lightweight and durable fabric (<500 g per garment) consisting of a proprietary barrier film laminated to a heavy duty Tyvek® substrate. They offer excellent chemical permeation protection to an extensive range of chemicals, helping to protect personnel against numerous toxic industrial organic chemicals, highly concentrated inorganic chemicals (even under pressure), particulates, biohazards and certain chemical warfare agents.

Supplier: Molecular Devices

An affordable, one touch, full spectrum micro volume spectrophotometer, ideal for quantification of very small quantities of DNA, RNA, proteins, amino acids and peptides – a critical first step in many molecular biology, biochemistry and genetics workflows. Additionally, this unit is also suitable for many more general absorbance-based applications, including quality control and testing.

Supplier: BURKLE

TeleScoop is a versatile sampling system with exchangeable tools for a wide range of applications. The tools (angular beaker, pendulum beaker, bottle holder, stainless steel beaker and dip net) are attached to the telescopic rod by a practical snap-in joint. Ideal for sampling from baths, tanks, shafts, open water courses. Sampling depths down to 6 m can be reached with the adjustable telescopic aluminium rod.

Supplier: OMEGA BIO-TEK

Mag-Bind® Viral DNA/RNA Xpress Kit CE IVD follows a magnetic bead-based approach for the rapid and reliable isolation of viral DNA and RNA from nasopharyngeal (NP) swab specimens that are dry or in viral transport media (VTM), from saliva and other sample sources.

Supplier: OMEGA BIO-TEK

Automation-ready, prefilled 96-well plates for quick and convenient DNA extraction from blood, saliva, cultured cells, and swabs for magnetic processors.

Supplier: IKA

Compact stirrers with a chemically resistant ceramic top. The elevated control panel minimises contact with spills and enables easy reading and adjustment of the temperature. Units feature a digital error code display, a 'hot' top indicator to warn user that surface is hot and the strong magnetic adhesion prevents stirring bar decoupling.

Supplier: HONEYWELL SAFETY

These fully reversible chainmail gloves are equipped with heavy duty adjustable straps and press stud fastening. They combines safety, quality and comfort, protecting against cuts, a common hazard in the meat and processing industries.

Supplier: IKA

Modular laboratory reactor for the optimisation and reproduction of various chemical reactions, mixing and homogenisation processes on a lab scale. The system is characterised by the agitator mounting, which allows a safe transfer of the higher motor torque.

Supplier: OHAUS

Stable, long-term shaking with triple eccentric drive and maintenance-free brushless DC motor.

Supplier: TESTO

The testo 760-3 digital multimeter is the multitasker for all professionals in the electricity sector. It enables users to carry out both simple and demanding electrical measuring tasks more reliably than ever before. The testo 760-3 automatically detects the appropriate measurement parameter via the socket assignment and therefore prevents dangerous incorrect settings.

Supplier: ANSELL MEDICAL PRODUCTS

The Gammex® Latex glove is easily donned, even with damp hands. The micro-rough textured outer surface ensures a secure grip in wet or dry conditions to facilitate the most delicate instrument handling.

Supplier: Portwest

The boot height ensures the ankle is protected and supported, with an angled top line for better fit and leg flexibility. A padded collar offers exceptional comfort.

Supplier: Thermo Fisher Scientific

These columns offer a high shape selectivity for hydrophobic, long chain, structurally-related isomers. Based on Core Enhanced Technology, they provide fast, high resolution separations without the elevated back pressures required by sub-2 µm particles.

Supplier: Showa

These breathable, waterproof and insulated PU coated gloves provide warmth and protection from liquids in cold conditions.

Supplier: Thermo Orion

The Thermo Scientific™ Orion™ Pro Star PI214 pH/ion bench meter is designed to provide accurate, reliable electrochemistry testing. Featuring an intuitive interface, enhanced data reporting and robust functionality, the Orion™ Pro Star PI214 meter delivers advanced performance in a modern and simplified package.

Supplier: Thermo Fisher Scientific

HyperSep™ Retain™ PEP polymeric SPE material is a high purity, highly porous polystyrene DVB (divinyl benzene) material modified with urea functional groups to give balanced retention of polar and non polar analytes. HyperSep™ Retain™ PEP is ideal for a wide range of applications, such as drugs and metabolites in biological fluids, peptides in serum, plasma or biological fluids and environmental fluids.

Supplier: GA

The DYMO® LabelWriter™ 550 is a direct thermal printer that does not require costly inks or toner to print high-quality text and barcodes, while its compact design allows it to fit seamlessly into any workspace.

Supplier: Thermo Orion

The Thermo Scientific™ Orion™ Pro Star PI217 dual channel pH/ion bench meter is designed to provide accurate, reliable electrochemistry testing. Featuring an intuitive interface, enhanced data reporting and robust functionality, the Orion™ Pro Star PI217 meter delivers advanced performance in a modern and simplified package.