2465 Results for: "STEMCELL Technologies"

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2b, antibody against human, chimpanzee, CD45RA, APC-Cyanine7-conjugated.

Supplier: STEMCELL Technologies

Dulbecco's Phosphate Buffered Saline with 2% fetal bovine serum is recommended for use as a buffer to dilute or wash nucleated cells.

Supplier: STEMCELL Technologies

Supplement for the differentiation of mouse naïve CD4+ T cells into Th2 cells.

Supplier: STEMCELL Technologies

Column-free immunomagnetic positive selection of human CD66b+ cells for HLA analysis.

Supplier: STEMCELL Technologies

Immunomagnetic negative selection kit.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against human, mouse, rhesus CD11b, biotin-conjugated.

Supplier: STEMCELL Technologies

Hamster (Armenian) monoclonal IgG antibody against mouse CD11c, biotin-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD2, FITC-conjugated.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2a antibody against mouse Ly-6G, Pacific Blue™-conjugated.

Supplier: STEMCELL Technologies

Hamster (Armenian) monoclonal IgG antibody against mouse CD11c.

Supplier: STEMCELL Technologies

Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor and a member of the tumor growth factor (TGF)-beta superfamily. The GDNF family of growth factors also includes neurturin, persephin, and artemin, which have seven conserved cysteine residues called cysteine-knots (Treanor et al.). GDNF family ligands signal through binding to specific GDNF-family receptor-α (GFRα) co-receptors and activate the RET receptor tyrosine kinase (Durbec et al.). Four different forms of GFRα co-receptors have been characterized (GFRα 1-4); GDNF binds specifically to GFRα1 prior to forming a complex with RET (Airaksinen and Saarma). GDNF is known to promote survival and morphological differentiation of midbrain dopaminergic neurons in both in vivo and in vitro studies and increases their high-affinity dopamine uptake (Granholm et al.; Lin et al.). GDNF has also been shown to have restorative effects on dying dopaminergic neurons in response to degenerative toxins (Aoi et al.). GDNF, together with Human Recombinant BDNF (brain-derived neurotrophic factor), BrainPhys™ Neuronal Medium, and other supplements, can be used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Bardy et al.).

Supplier: STEMCELL Technologies

Amphiregulin is a member of the epidermal growth factor (EGF) family. It binds to several receptors including EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3, and HER4/ErbB4, which activates Ras/Raf/MAPK and PI3K/AKT pathways. This results in cell proliferation, apoptosis resistance, and invasive behaviour (Normanno et al.). The expression of amphiregulin is induced by tissue injury and inflammation. Amphiregulin promotes mammary development, trophoblast growth, lung and kidney branching morphogenesis, and keratinocyte proliferation. It stimulates the growth of most cell types, including normal and transformed mammary epithelial cells, and malignant cells of the colon, prostate, cervix, and pancreas (Berasain and Avila).

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD32, FITC-conjugated.

Supplier: STEMCELL Technologies

Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.).

Supplier: STEMCELL Technologies

TRAIL (TNF-related apoptosis-inducing ligand) belongs to the tumor necrosis factor (TNF) superfamily and is associated with initiating apoptosis. TRAIL has four major receptors: two death receptors DR4 and DR5, and two decoy receptors DcR1 and DcR2. TRAIL binds to the death receptors, which recruits the Fas-associated death domain (FADD) and activates caspases 8 and 10, which eventually leads to apoptosis (Pitti et al.; Wiley et al.; Zauli and Secchiero). It has been shown that mice lacking the expression of TRAIL have defects in thymocyte apoptosis and negative selection, and these mice had increased susceptibility to autoimmune diseases (Lamhamedi-Cherradi et al.).

Supplier: STEMCELL Technologies

Influenza (HLA class I control) peptide pool is a lyophilised mixture of 17 peptides from the influenza virus. The pool consists of defined HLA class I-restricted T cell epitopes, and can be used as an antigen-specific positive control to stimulate T cells.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human naïve CD4+ T cells.

Supplier: STEMCELL Technologies

Serum-free medium kit for highly efficient SMAD inhibition-mediated neural induction of human ES and iPS cells.

Supplier: STEMCELL Technologies

For detection and measurement of human immunoglobulin E.

Supplier: STEMCELL Technologies

Defined medium kit for transgene-free induction of reset naïve human pluripotent stem cells - 1 Kit

Supplier: STEMCELL Technologies

Serum-free media for generation and maturation of branching lung organoids from human ES and iPS cells.

Supplier: STEMCELL Technologies

SARS-CoV-2 Recombinant Spike Protein, aa16-685 is expressed in HEK293 cells and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Spike Protein plays a key role in attachment to host cells, allowing invasion through clathrin-mediated endocytosis. The Spike Protein can be cleaved by host cell proteases after aa685 to yield the N-terminal S1 subunit and C-terminal S2 region. The S1 subunit is responsible for interacting with the host cell receptor (angiotensin-converting enzyme II) through a receptor-binding domain that is highly conserved with SARS-CoV. The S1 subunit has two conformations: a ‘down’ conformation in which the receptor is inaccessible, and an ‘up’ conformation in which the receptor is accessible. These conformational changes are key for monoclonal antibody drugs and vaccine development. SARS-CoV-2 Recombinant Spike Protein contains a polyhistidine tag at the amino terminus; it also contains a FLAG tag at the carboxy terminus.

Supplier: STEMCELL Technologies

For differentiation of human ES or iPS cells into erythroid progenitor cells.

Supplier: STEMCELL Technologies

Mouse monoclonal antibody against human, rhesus, cynomolgus CD9, unconjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1, antibody against human, chimpanzee CD4, APC-conjugated.

Supplier: STEMCELL Technologies

A cellular protein for detection of apoptotic cells, APC-conjugated.

Supplier: STEMCELL Technologies

Amine-labelling fluorescent dye for live/dead staining of mammalian cells - 100 tests.

Supplier: STEMCELL Technologies

Serum-free and xeno-free base medium for the expansion of B cells.

Supplier: STEMCELL Technologies

Serum-free and conditioned medium-free cell culture medium for establishment and maintenance of human intestinal organoids.

Supplier: STEMCELL Technologies

The SARS-CoV-2 (VME1) peptide pool is a lyophilised mixture of 53 peptides from the SARS-CoV-2 membrane protein VME1. VME1 is a structural protein that is common to all coronaviruses, and it plays a critical role in viral assembly. The pool consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 222 on VME1.