5270 Results for: "ENZO LIFE SCIENCES"

Supplier: ENZO LIFE SCIENCES

Immunohistochemistry (mouse/rabbit-HRP) detection reagent is a non-biotin one-step detection reagent.

Supplier: ENZO LIFE SCIENCES

cADPR antagonist.

Supplier: ENZO LIFE SCIENCES

K⁺ channel activator.

Supplier: ENZO LIFE SCIENCES

Calcium dye

Supplier: ENZO LIFE SCIENCES

The Screen-Well® cardiotoxicity library is a focused collection of 130 compounds with defined and diverse cardiotoxicity, including ion channel blockage, mitochondrial toxicity, arrhythmia, fibrosis, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

Supplier: ENZO LIFE SCIENCES

Host: Mouse, Isotype: IgG2a

Supplier: ENZO LIFE SCIENCES

Anti-HSP25 + HSP27 Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

Recommended Applications: WB

Species reactivity: Species independent

Supplier: ENZO LIFE SCIENCES

Inhibitor of PI3Kγ, PI3Kδ, FRAP, Akt and VEGF.

Supplier: ENZO LIFE SCIENCES

Produced in HEK 293 cells. The extracellular domain of human Fas (CD95; APO-1) (aa 7-154) is fused to the Fc portion of human IgG1.

Supplier: ENZO LIFE SCIENCES

Anti-Proteasome 19S Rpn10/S5a subunit Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

Shikonin inhibits TNF-α- and B6 melanoma-induced angiogenesis in mice. It blocks expression of integrin αvβ3 and inhibits endothelial cell proliferation and migration in vitro.

Supplier: ENZO LIFE SCIENCES

Ansamitocin P-3 is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. It shares the same binding site as rhizoxin and phomopsin A on porcine brain tubulin. Maytansine and its analogs cause extensive disassembly of the microtubule and totally prevent tubulin spiralization.

Supplier: ENZO LIFE SCIENCES

Inhibitor of caspase-1 and -4

Supplier: ENZO LIFE SCIENCES

TLR4 activator.

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HSFs (Heat Shock family of transcription factors), which consists of HSF 1-4, bind to highly conserved Heat shock elements (HSEs) in the promoter regions of heat shock genes, ultimately regulating the expression of Heat shock proteins (Hsps). On exposure to heat shock and other stresses, HSF1 localizes within seconds to discrete nuclear granules and on recovery from stress, HSF1 rapidly dissipates from the stress granules to a diffuse nucleoplasmic distribution.

Supplier: ENZO LIFE SCIENCES

Analog of microcystin-LR (Prod. No. ALX-350-012) with Tyr substituted in place of Arg.

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Anti-NGAL Mouse Monoclonal Antibody [clone: 28]

Supplier: ENZO LIFE SCIENCES

Host: Mouse, Isotype: IgG1

Supplier: ENZO LIFE SCIENCES

The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.

Supplier: ENZO LIFE SCIENCES

TRAIL decoy receptors (DcR1, DcR2, and osteoprotegerin/OPG) completely or partially lack the signaling death domain, and/or are secreted from cells and unable to transmit intracellular signals.

Supplier: ENZO LIFE SCIENCES

MG-132 is a potent, cell permeable and selective proteasome inhibitor (Ki = 4 nM).1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3 μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1 μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20 nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0,85 and 0,1 μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.

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Produced in insect cells.

Supplier: ENZO LIFE SCIENCES

A selective estrogen receptor modulator (SERM). Displays anti-estrogen action along with anti-androgen action. In clinical use for prevention of postmenopausal osteoporosis. Reduces circulating levels of IL-6 and TNFα. Inhibits prostate carcinogenesis in transgenic rat model. May be useful for the prevention of hormone-related cancers.

Supplier: ENZO LIFE SCIENCES

EGTA buffer, 2X

Supplier: ENZO LIFE SCIENCES

Fibronectins are high molecular weight, disulphide-linked, dimeric cell adhesion glycoproteins found in basement membranes and in the interstitial connective tissue matrix. A single fibronectin gene is subject to alternative splicing in a cell-type-, development- and age-regulated manner which gives rise to multiple molecular forms. In addition to their prominent role in adhesion, fibronectins have been reported to mediate various aspects of cellular interaction, including migration during development and wound-healing, haemostasis, and the regulation of cell growth and differentiation. Cellular fibronectins (cFn) are found in low amounts in normal human plasma and tissues, but they are abundant in the plasma of carcinoma patients and in the stroma of various carcinomas. In contrast, a soluble form of fibronectin produced by hepatocytes is readily detectable in plasma and becomes deposited in pericellular matrices and within tissues. This form of fibronectin, referred to as ‘plasma fibronectin’ (pFn), differs from cFn by the absence of an amino acid sequence, known as extra domain A1.

Supplier: ENZO LIFE SCIENCES

The Screen-Well® myotoxicity library is a focused collection of 60 compounds with defined and diverse myotoxicity, including rhabdomyolysis, cardiomyopathy, mitrochondrial myopathy, vacuolar myopathy, and more. A variety of structurally and mechanistically different compound classes are included, as well as non toxic controls. All compounds are dissolved in DMSO at 10 mM unless otherwise stated in the documentation provided with the library. Selected compounds are dissolved in DI water. All compounds are provided at 100 µl volumes in a 96-Well plate.

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Isolated from bovine eye lens.

Supplier: ENZO LIFE SCIENCES

Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg²⁺ ions and rapidly inactivated by N-acetylimidazole.

Supplier: ENZO LIFE SCIENCES

Caspase-2 inhibitor