5269 Results for: "ENZO LIFE SCIENCES"

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Highly selective NK-3 neurokinin receptor agonist

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Host: Mouse, Isotype: IgG3

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1. Ubiquitinylation of specific endogenous HeLa lysate proteins, followed by their immediate detection/analysis using antibodies to the protein/s of interest, indicating a particular protein is a substrate for the ubiquitin-proteasome pathway. 2. Ubiquitinylation of proteins of interest contained in exogenously added expression culture/cell extracts or tissue lysates/extracts, followed by their immediate detection/analysis or isolation/purification for use in subsequent experiments. 3. Modification of proteins using ubiquitin derivatives or mutants for improved detection/analysis or investigation of alternative (non-proteasomal) ubiquitin related pathways in subsequent experiments. For example, biotinylated-ubiquitin (Prod. No. BML-UW8705), for sensitive detection

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Produced in E. coli. Active Matrix Metalloproteinase-13 (MMP-13, collagenase-3) catalytic domain from human cDNA.

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Produced in E. coli. Non-glycosylated protein, containing 154 amino acids.

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Cellular assay, Cell counting kit-8

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TLR4 activator.

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CGH labelling kit for BAC arrays has been optimised to label DNA for dual sample comparative genomic hybridisation (CGH) assays on BAC arrays. It is suitable for the preparation of cyanine 3- and cyanine 5-labelled DNA for hybridisation to BAC arrays.

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CaM kinase inhibitor

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Negative control for C2 ceramide.

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Potent and orally active Lck/Src inhibitor.

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Highly active

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Host: Rabbit

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Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.

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Caspase inhibitor

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Beclin-1 is a coiled-coil Bcl-2-interacting protein that functions in autophagy, the process of bulk degradation of cellular proteins. Beclin-1 is homologous to the yeast autophagy gene apg6, and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as both an anti-autophagic and anti-apoptotic protein.

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Cathepsin-L inhibitor

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Anti-p47Phox, NCF1 Rabbit Polyclonal Antibody

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Fatty acid synthase inhibitor

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The GABAergic igands library contains 56 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The GABAergics ligands plate is 1 plate of the larger neurotransmitter library which contains over 650 CNS receptor ligands.

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Trk ligand

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Produced in HEK 293 cells. The cysteine-rich region of human CD134 (OX40) (aa 29-214) is fused to the Fc portion of human IgG1.

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Host: Rat, Isotype: IgG2a

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Fas/APO-1/CD95 is a 36 kDa cell surface type I-membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS-PAGE.  Fas belongs to the tumor necrosis factor receptor (TNFR) family, which includes TNFR1, TNFR2, CD27, CD30 and CD40.  Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis of Fas expressing cells.  Both Fas and TNFR contain a 70 amino acid cytoplasmic “death domain” responsible for transmitting signals for apoptosis.  Apoptosis induced by Fas-Fas ligand interaction is inhibited by a number of cytosolic factors such as the ICE/CED3 family inhibitor CrmA, and the short and long forms of FLIP. Insertion of an early transposable element in intron 2 of the Fas gene, as in the mouse lpr mutations, causes lymphoproliferation and autoimmunity in mutant mice, suggesting the involvement of Fas in clonal deletion of autoreactive T cells.

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This peptide, EDPIYEFLPAKKK, was identified through phage display as a high affinity substrate for both Lyn kinase (Km=24 µM) and Syk kinase (Km=17 µM).

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PKA inhibitor

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Produced in E. coli. E. coli thioredoxin is fused at the N-terminus to a His-tag.

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Potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase (NAALADase), which is a membrane-bound peptidase that hydrolyses N-acetyl-L-aspartate-L-glutamate (NAAG), a major brain peptide.

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Host: Mouse, Isotype: IgG1

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A puromycin analog which does not inhibit protein synthesis or induce apoptosis. It is a glomerular epithelial cell toxin which may be used to induce nephropathy in laboratory animals.