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The mammalian homologs of the Ced-4 proteins, Apaf-1 (Ced-4), Nod1 (CARD4), and Nod2 contain a caspase recruitment domain (CARD) and a putative nucleotide binding domain, signified by a consensus Walker's A box (P-loop) and B box (Mg2+-binding site) 1 * 100 µG

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SH3BGRL (SH3 domain binding glutamic acid-rich protein like), also known as SH3BGR, is a 114 amino acid protein that is ubiquitously expressed and is encoded by a gene which maps to the X chromosome of both human and mouse. 1 * 100 µG

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The heat shock proteins (HSPs) comprise a group proteins with diverse functions, including the assembly and sequestering of multi-pr otein complexes, the transportation of nascent poly-peptide chains across cellular membranes and the regulation of pr 1 * 100 µG

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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cel lular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded prote 1 * 100 µG

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NDUFA1 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1), also known as ZNF183 or MWFE, is one of about 45 subunits comprising Complex I of the oxidative phosphorylation electron transport chain. 1 * 100 µG

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This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encod ed protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic 1 * 100 µG

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The protein kinase superfamily contains over a thousand proteins in 57 subfamilies that all share a catalytic core of 250–300 amino acids organized in two domains. 1 * 100 µG

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SH2D4A (SH2 domain containing protein 4A), also known as SH2A, is a ubiquitously expressed 454 amino acid docking protein that belon gs to the SH2 signaling protein family. 1 * 100 µG

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The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix- turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. 1 * 100 µG

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c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yi eld 10 isoforms through alternative mRNA splicing. 1 * 100 µG

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UDP-glucuronosyltransferase isoenzymes (UGTs) catalyze the glucuronidation of small lipophilic molecules, thereby regulating the bio activity and metabolic fate of a wide range of endogenous compounds and xenobiotics. 1 * 100 µG

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Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcri ptional activation or repression. 1 * 100 µG

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The Ca2+/calmodulin-dependent protein kinases (CaMKs) comprise a structurally related subfamily of serine/threonine kinases. CAMKV ( CaM kinase-like vesicle-associated), also known as 1G5 or VACAMKL,. 1 * 100 µG

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Class E vacuolar protein sorting (vps) proteins are necessary for appropriate sorting of receptors in the yeast endocytic pathway. T he yeast Vps4p is a member of the AAA protein family (ATPases associated with diverse cellular activities). 1 * 100 µG

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The mammalian zona pellucida is composed of three major glycoproteins, ZP1, ZP2 and ZP3. ZP2 has been implicated as a secondary sper m receptor that binds sperm only after the induction of the sperm acrosome reaction. 1 * 100 µG

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GTPase-activating proteins(GAPs) accelerate the intrinsicrate of GTP hydroysis of Ras-related proteins, resulting in downregulation of their active form.RN-tre (related to the N-terminus of tre), also known as USP6NL(USP6 Nterminal like) or TRE2NL. 1 * 100 µG

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The Ku protein islocalized in the nucleus and iscomposed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86). Ku wasfirst d escribed as an autoantigen to which antibodies were produced in a patient with scleroderma polymyositis overlap syndr 1 * 100 µG

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Activity-dependent neuroprotector homeobox is a protein that in humans is encoded by the ADNP gene.Diseases associated with ADNP inc lude helsmoortel-van der aa syndrome and adnp-related multiple congenital anomalies-intellectual disability-autism sp 1 * 100 µG

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NKp46 (lymphocyte antigen 94, LY94) is a natural cytotoxicity receptor that belongs to the immunoglobulin superfamily and is express ed by all resting or activated NK cells, but not on T cells or B cells. 1 * 100 µG

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Glucokinase (also designated hexokinase IV, HXKIV or GCK) plays a key role in the regulation of glucose-induced insulin secretion. G CK is expressed in pancreatic beta cells where it functions as the major glucose sensor of the body, determining the 1 * 100 µG

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The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus e 1 * 100 µG

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Cells undergoing apoptosis lose the asymmetry of plasma membrane phospholipids, and phosphatidylserine is exposed on the outer surfa ce of the membrane. The phosphatidylserine receptor (PSR) specifically recognizes phosphatidylserine . 1 * 100 µG