Single-use bioreactor systems, BIOne

Distek, Inc. has developed a bench top scale single-use bioreactor (SUB) for mammalian cell growth, cell therapy, insect cells and other unique applications performed in a stirred tank bioreactor. The gamma irradiated BIOne SUB is engineered with a disposable head plate welded to a triple-layered liner that can be easily inserted into a non sterile bioreactor glass vessel, converting it to a disposable SUB within a matter of seconds.

• Customisable above and below the head plate
• 2 and 5 L working volume
• Optional single-use pH probe
• Increased throughput
• Weldable tubing
• Non invasive DO probe port
• USP class VI materials
• Animal derivative-free and low antioxidant liner material
• Compatible with most manufacturers’ glass vessels and controllers

Upon media addition, the liner expands and moulds to the glass vessel, preserving the geometry of the existing bioreactor. The BIOne SUB’s liner material emulates the large-scale SUBs used in pilot and commercial biopharma production facilities around the world. Performing R&D studies using the most similar material on the market streamlines your tech transfer and can de-risk your process before transferring to pilot scale.

Ordering information: Requires one BIOne starter kit (P/N 2800-0510) for each controller being converted for use with the BIOne SUB. Requires one BIOne motor adapter assembly for each controller being converted for use with the BIOne SUB. Motor adapters are controller motor-specific. For more details please contact your local Avantor sales office.