AdipoRon is an orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 with KD values of 1.8 and 3.1 µM, respecti vely.{25721} At 50 mg/kg, it acts similarly to adiponectin, activating AMPK and PPARα pathways and reducing insulin r 1 * 10 mg