Human Recombinant OGG1 (from E. coli)
Catalog # NOVUNBP1-45318-0.1
Supplier: Novus Biologicals
New Product
CAS Number:
Specifications
- Pk:0,1 mg
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Storage conditions:Store at 4 °C short term. Aliquot and store at −20 °C long term. Avoid freeze-thaw cycles.
- Protein synonyms:MMH|MUTMOGH1HMMH|N-glycosylase/DNA lyase|HOGG1|OGG1|8-oxoguanine DNA glycosylase|AP lyase|DNA-apurinic or apyrimidinic site lyase|8-hydroxyguanine DNA glycosylase
- Protein/peptide name:OGG1
- Purity:>90%, by SDS-PAGE
- Molecular weight:41,2 kDa
- Sequence:MGSSHHHHHH SSGLVPRGSH TGSMPARALL PRRMGHRTLA STPALWASIP CPRSELRLDL VLPSGQSFRW REQSPAHWSG VLADQVWTLT QTEEQLHCTV YRGDKSQASR PTPDELEAVR KYFQLDVTLA QLYHHWGSVD SHFQEVAQKF QGVRLLRQDP IECLFSFICS SNNNIARITG MVERLCQAFG PRLIQLDDVT YHGFPSLQAL AGPEVEAHLR KLGLGYRARY VSASARAILE EQGGLAWLQQ LRESSYEEAH KALCILPGVG TKVADCICLM ALDKPQAVPV DVHMWHIAQRDYSWHPTTSQ AKGPSPQTNK ELGNFFRSLW GPYAGWAQAV LFSADLRQCR HAQEPPAKRR KGSKGPEG
- Concentration:0,5 mg/ml
- Tested applications:PAGE
Specifications
About this item
OGG1, also known as 8-oxoguanine glycosylase, is a DNA glycosylase enzyme involved in base excision repair. This protein is the primary enzyme responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen species (ROS).
It has a beta lyase activity that nicks DNA 3' to the lesion. Recombinant human OGG1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Caution: This product is for research use only and is not approved for use in humans or in clinical diagnosis.