Human Recombinant TGF-alpha

Transforming growth factor-alpha (TGF-α) a member of the epidermal growth factor (EGF) family that is expressed in normal epithelial cells, monocytes, macrophages, brain cells, keratinocytes, and cancer cells. TGF-α binds EGF receptor (EGFR) and activates tyrosine kinase signaling. In epidermal and epithelial cells, this results in proliferation and differentiation. TGF-α is not structurally or genetically related to TGF-β, and the two ligands act through different signaling pathways. In vitro, TGF-α was shown to stimulate anchorage-independent growth (Singh and Coffey).

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Protein/peptide type:
Recombinant
Species:
Human
Protein/peptide name:
TGF-alpha
Purity:
≥95%