- Antibody type:Primary
- Antigen name:SRP1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitope:81-180/538
- Form:Liquid
- Gene ID:3838
- Antigen synonyms:Nucleoprotein interactor 1|Karyopherin alpha 1 subunit|NPI 1|SRP1 beta|Importin alpha 1 subunit|IPOA5|SRP 1|Importin alpha S1|RCH2|NPI-1|mSRP 1|SRP1-beta|Karyopherin alpha 1|mSRP1|Karyopherin subunit alpha-1|RCH 2|RAG cohort protein 2|KPNA1|KPNA 1|Recombination activating gene cohort 2|NPI1|IMA1_HUMAN|Importin subunit alpha-1|IPOA 5|IPO A5|Importin alpha 5
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Storage temperature:Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human SRP1/karyopherin alpha 1
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors that mediate protein passage through the nuclear pore complex (NPC). Cytoplasmic proteins that contain nuclear localisation signals (NLSs) must be recognised as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Karyopherin alpha 1 and karyopherin alpha 6 are widely expressed nuclear import proteins that act as adaptors for karyopherin 1, specifically binding to and guiding NLS-containing proteins to the NPC. Both karyopherin alpha 1 and karyopherin alpha 6 contain one IBB domain and ten ARM repeats through which they convey their protein binding and localisation function. Together, karyopherin å1 and karyopherin å6 are responsible for ensuring the nuclear import of NLS-containing substrates
Type: Primary
Antigen: SRP1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 81-180/538
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat