Specifications
- Antibody type:Primary
- Antigen name:MCM4/CDC21
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Western blot:Yes
- Epitope:761-863/863
- Form:Liquid
- Antigen synonyms:KIAA4003|MCM4 minichromosome maintenance deficient 4, mitotin S, cerevisiae|DNA replication licensing factor MCM 4|CDC 54|Minichromosome maintenance deficient 4|MCM 4 minichromosome maintenance deficient 4|Minichromosome maintenance, S, cerevisiae, homolog of, 4|AU045576|mcdc21|P1 CDC21|hCdc21|P1CDC21|MGC33310|P1-CDC21|19G antibody AI325074|Minichromosome maintenance deficient S, cerevisiae 4|mKIAA4003|CDC54|Mcmd4|Minichromosome maintenance complex component 4|MCM4_HUMAN|CDC21|CDC 21|Minichromosome maintenance deficient 4 homolog S, cerevisiae|MCM4|MCM4 minichromosome maintenance deficient 4|DNA replication licensing factor MCM4|CDC21 homolog|Homolog of S, pombe cell devision cycle 21|hCdc 21|Minichromosome Maintenance 4|MCM 4
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:96 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human MCM4
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2-6) during apoptosis.
Type: Primary
Antigen: MCM4/CDC21
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 761-863/863
Host: Rabbit
Isotype: IgG
Reactivity: