- Antibody type:Primary
- Antigen symbol:DopamineR D2
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Seq:02
- Epitope:near the N-Terminus
- Form:Liquid
- Storage buffer:PBS containing 50% glycerol and 0.01% sodium azide.
- Storage temperature:–20 °C
- Shipping temperature:Shipped on blue ice
- Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of mouse dopamine receptor D2
- Purification:purified by peptide affinity chromatography
- Pk:100 µG
Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain, where it regulates locomotor, emotional, memory, and dietary intake functions, as well as peripheral roles such as hormone secretion and renal function. Dopamine receptors (D1-D5) are members of the seven transmembrane domain containing GPCR family, and are the target of several anti-psychosis and anti-Parkinsonian drugs. The D2, D3, and D4 receptors signal via coupling of Gi/Go alpha G-protein subunits to inhibit adenylyl cyclase activity and modulate cellular potassium and calcium ion channel conductance. Expression of the D2 receptor is found primarily in the brain (striatum, olfactory tubercle, and nucleus accumbens) and in the anterior and intermediate lobes of the pituitary.
Type: Primary
Antigen: DopamineR D2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: near the N-Terminus
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat