About this item
Recognizes a protein of 42-46 kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8 T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
Type: Primary
Antigen: MAGEA1
Clonality: Monoclonal
Clone: MA454
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Dog, Human, Rat
Specifications
- Catalog No:
- BNC880008-500
- BNC880008-100
- Antigen symbol:
- MAGEA1
- MAGEA1
- Antigen name:
- MAGE A1
- MAGE A1
- Antigen synonyms:
- Melanoma associated antigen 1|CT1.1|Melanoma antigen family A 1|MAGE1A|MAGEA1|cancer/testis antigen 1.1|Melanoma associated antigen MZ2 E|MZ2 E
- Melanoma associated antigen 1|CT1.1|Melanoma antigen family A 1|MAGE1A|MAGEA1|cancer/testis antigen 1.1|Melanoma associated antigen MZ2 E|MZ2 E
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 488A
- CF® 488A
- Clone:
- Clone MA454
- Clone MA454
- Reactivity:
- Human, Dog, Rat
- Human, Dog, Rat
- Host:
- Mouse
- Mouse
- Gene ID:
- 72879
- 72879
- Isotype:
- IgG1 kappa
- IgG1 kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide