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Human recombinant osteopontin (from HEK293 cells)
  PRSI96-569
 :  
undefined
Human recombinant osteopontin (from HEK293 cells)
  PRSI96-569
 :  

 

  • Pk:
    100 µG
  • Protein/peptide type:
    Recombinant
  • Source:
    HEK293 cells
  • Species:
    Human
  • Protein synonyms:
    ETA-1|Nephropontin|BSP-1|OPN|BNSP|BSPI|Uropontin|SPP1|Osteopontin
  • Protein/peptide name:
    Osteopontin
  • Purity:
    >80% as determined by SDS-PAGE.
  • Molecular weight:
    33 kDa
  • Formulation:
    Lyophilized, PBS, pH7.4
  • Tested applications:
    Western Blot

 

 

Osteopontin (OPN) is also known as Secreted phosphoprotein 1 (SPP1), Bone sialoprotein 1, Nephropontin, Urinary stone protein, Uropontin, BNSP, which belongs to the osteopontin family. OPN / SPP1 is a highly negatively charged, extracellular matrix protein that lacks an extensive secondary structure. Full length OPN (OPN-FL) can be modified by thrombin cleavage, which exposes a cryptic sequence, SVVYGLR on the cleaved form of the protein known as OPN-R. Osteopontin / SPP-1 is biosynthesized by a variety of tissue types. OPN is the ligand for integrin alpha-V/beta-3. OPN / SPP1 binds tightly to hydroxyapatite and appears to form an integral part of the mineralized matrix. OPN / SPP1 probably important to cell-matrix interaction. OPN / SPP1 acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.