2418 Results for: "STEMCELL TECHNOLOGIES"

Supplier: STEMCELL TECHNOLOGIES

Serum-free medium for culture and expansion of hematopoietic cells.

Supplier: STEMCELL TECHNOLOGIES

Ammonium chloride solution is recommended for the lysis of red blood cells (RBCs) in preparations of human and mouse peripheral blood, spleen or bone marrow cells. It is buffered and optimised for gentle lysis of erythrocytes, with minimal effect on leukocytes. It does not contain a fixative agent, therefore leukocytes are viable following RBC lysis.

Supplier: STEMCELL TECHNOLOGIES

Animal component-free, defined hypothermic (2 to 8 °C) preservation medium for a range of cell and tissue types.

Supplier: STEMCELL TECHNOLOGIES

For neural differentiation of mouse ES and iPS cells.

Supplier: STEMCELL TECHNOLOGIES

Interleukin 22 (IL-22) is a class 2 α-helical cytokine that signals through the class 2 cytokine receptor and activates the JAK/STAT pathway. IL-22 is secreted by Th1, Th2, Tc22, and γδ T cells, dendritic, mast and NK cells. It stimulates expression of antimicrobial peptides from epithelial cells, thus hindering bacterial infections. Depending on the interactions with other cytokines, IL-22 can either promote inflammation or prevent tissue destruction by regulating host defense and tissue homeostasis at barrier surfaces (Sonnenberg et al.).

Supplier: STEMCELL TECHNOLOGIES

Insulin-like growth factor 2 (IGF-II) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-II binding to IGF-I receptor activates a signaling cascade via the MAPK and PI3K pathways. IGF-II affects growth, differentiation, and survival of cells in a variety of tissues during embryonic development. It stimulates proliferation and migration of primary lymphatic endothelial cells, and induces lymphangiogenesis (Guvakova).

Supplier: STEMCELL TECHNOLOGIES

Rat monoclonal IgG2a antibody against mouse Ly-6G, PerCP-Cy5.5-conjugated.

Supplier: STEMCELL TECHNOLOGIES

Rat monoclonal IgG2a antibody against mouse CD62L (L-selectin), Alexa Fluor® 488-conjugated.

Supplier: STEMCELL TECHNOLOGIES

Basic fibroblast growth factor (bFGF) is a prototypic member of the fibroblast growth factor family. Cytokines in the FGF family possess broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and are involved in a variety of biological processes including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). bFGF has the β-trefoil structure (Ponting and Russell), binds to the four FGF receptor (FGFR) family members, and activates JAK/STAT, PI3K, ERK1/2, and other receptor tyrosine kinase (RTK) signaling pathways. It supports the maintenance of undifferentiated human embryonic stem cells (Xu et al.; Kang et al.), stimulates human embryonic stem cells to form neural rosettes (Zhang et al.), and improves proliferation of human mesenchymal stem cells and enhances chondrogenic differentiation (Solchaga et al.).

Supplier: STEMCELL TECHNOLOGIES

Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic growth factor that promotes proliferation, motility, survival, and differentiation. HGF binds and promotes the dimerization and activation of the receptor tyrosine kinase c-MET, and stimulates PI3K/AKT, FAK, JNK, and ERK1/2 signaling (Organ and Tsao). HGF stimulates migration of cells during embryogenesis, induces cell motility and scattering of epithelial cells, and regulates epithelial-mesenchymal transition. It is a chemoattractant for motor neurons, and regulates the development of sensory, sympathetic, parasympathetic, and cortical neurons as well as the proliferation of oligodendrocytes and glial development. Additionally, HGF is cytoprotective and regulates liver growth and regeneration (Nakamura et al.).

Supplier: STEMCELL TECHNOLOGIES

A specialised media kit for improving plating efficiency post-thawing and post-harvesting of human pluripotent stem cell-derived cardiomyocytes.

Supplier: STEMCELL TECHNOLOGIES

cGMP, enzyme-free human pluripotent stem cell selection and passaging reagent.

Supplier: STEMCELL TECHNOLOGIES

Hamster (Armenian) monoclonal antibody against mouse T cell receptor beta, APC-conjugated.

Supplier: STEMCELL TECHNOLOGIES

Mouse monoclonal antibody against human, monkey CD137 (ILA).

Supplier: STEMCELL TECHNOLOGIES

Hamster (Armenian) monoclonal antibody against mouse T cell receptor beta, FITC-conjugated.

Supplier: STEMCELL TECHNOLOGIES

Mouse monoclonal antibody against human CD69 (AIM).

Supplier: STEMCELL TECHNOLOGIES

Rat monoclonal antibody against human IL-4, PE-conjugated.

Supplier: STEMCELL TECHNOLOGIES

Rat monoclonal antibody against mouse CD3, APC-conjugated.

Supplier: STEMCELL TECHNOLOGIES

Mouse monoclonal antibody against human, monkey CD137 (ILA).

Supplier: STEMCELL TECHNOLOGIES

cGMP, human T cell activation and expansion reagent.

Supplier: STEMCELL TECHNOLOGIES

A serum-free media kit for the expansion of early-stage human pluripotent stem cell-derived cardiomyocytes.

Supplier: STEMCELL TECHNOLOGIES

Immunomagnetic positive selection of human cells.

Supplier: STEMCELL TECHNOLOGIES

Immunomagnetic positive selection of non-human primate cells.

Supplier: STEMCELL TECHNOLOGIES

Rat monoclonal antibody against mouse CD8a, APC-conjugated.

Supplier: STEMCELL TECHNOLOGIES

Hamster (Armenian) monoclonal antibody against mouse CD69, APC-conjugated.

Supplier: STEMCELL TECHNOLOGIES

Immunomagnetic extraction of total nucleic acid (DNA and RNA).

Supplier: STEMCELL TECHNOLOGIES

For detection and measurement of human immunoglobulin E.

Supplier: STEMCELL TECHNOLOGIES

For detection and measurement of mouse interleukin 5.

Supplier: STEMCELL TECHNOLOGIES

For detection and measurement of human interleukin 10.

Supplier: STEMCELL TECHNOLOGIES

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG encoded common cytokine receptor γ-chain (Parrish-Novak et al.; Ozaki K et al. 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki et al. 2002; Nurieva et al.). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser et al.). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland et al.) and control of T cell autoimmunity by regulatory B cells (Yoshizaki et al.).